Intraoperative hyperthermia in conjunction with multi-schedule chemotherapy (pre-, intra- and post-operative), by-pass surgery, and post-operative radiotherapy for the management of unresectable pancreatic adenocarcinoma

Kouloulias, VE; Kouvaris, JR; Nikita, KS; Golematis, BC; Uzunoglu, NK; Mystakidou, K; Papavasiliou, C; Vlahos, L

dc.contributor.author	Kouloulias, VE	en
dc.contributor.author	Kouvaris, JR	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Golematis, BC	en
dc.contributor.author	Uzunoglu, NK	en
dc.contributor.author	Mystakidou, K	en
dc.contributor.author	Papavasiliou, C	en
dc.contributor.author	Vlahos, L	en
dc.date.accessioned	2014-03-01T01:17:59Z
dc.date.available	2014-03-01T01:17:59Z
dc.date.issued	2002	en
dc.identifier.issn	0265-6736	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14748
dc.subject	Intraoperative hyperthermia	en
dc.subject	Palliation	en
dc.subject	Quality of life	en
dc.subject	Radiotherapy with pre-operative plus intra-operative regional plus post-operative chemotherapy	en
dc.subject	Survival analysis	en
dc.subject	Unresectable pancreatic adenocarcinoma	en
dc.subject.classification	Oncology	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	antineoplastic agent	en
dc.subject.other	cisplatin	en
dc.subject.other	doxorubicin	en
dc.subject.other	fluorouracil	en
dc.subject.other	octreotide	en
dc.subject.other	adult	en
dc.subject.other	aged	en
dc.subject.other	alopecia	en
dc.subject.other	analgesia	en
dc.subject.other	article	en
dc.subject.other	asthenia	en
dc.subject.other	bone marrow suppression	en
dc.subject.other	cancer chemotherapy	en
dc.subject.other	cancer combination chemotherapy	en
dc.subject.other	cancer control	en
dc.subject.other	cancer growth	en
dc.subject.other	cancer palliative therapy	en
dc.subject.other	cancer staging	en
dc.subject.other	cancer survival	en
dc.subject.other	clinical article	en
dc.subject.other	clinical trial	en
dc.subject.other	controlled clinical trial	en
dc.subject.other	controlled study	en
dc.subject.other	correlation analysis	en
dc.subject.other	drug infusion	en
dc.subject.other	female	en
dc.subject.other	gastrointestinal disease	en
dc.subject.other	heating	en
dc.subject.other	human	en
dc.subject.other	hyperthermia	en
dc.subject.other	intraoperative period	en
dc.subject.other	male	en
dc.subject.other	pancreas adenocarcinoma	en
dc.subject.other	postoperative care	en
dc.subject.other	preoperative treatment	en
dc.subject.other	prognosis	en
dc.subject.other	quality of life	en
dc.subject.other	radiation beam	en
dc.subject.other	radiation dose	en
dc.subject.other	rank sum test	en
dc.subject.other	statistical significance	en
dc.subject.other	temperature	en
dc.subject.other	vomiting	en
dc.subject.other	Adenocarcinoma	en
dc.subject.other	Adult	en
dc.subject.other	Aged	en
dc.subject.other	Combined Modality Therapy	en
dc.subject.other	Female	en
dc.subject.other	Fluorouracil	en
dc.subject.other	Humans	en
dc.subject.other	Hyperthermia, Induced	en
dc.subject.other	Intraoperative Period	en
dc.subject.other	Male	en
dc.subject.other	Middle Aged	en
dc.subject.other	Pancreatic Neoplasms	en
dc.subject.other	Quality of Life	en
dc.subject.other	Survival Rate	en
dc.title	Intraoperative hyperthermia in conjunction with multi-schedule chemotherapy (pre-, intra- and post-operative), by-pass surgery, and post-operative radiotherapy for the management of unresectable pancreatic adenocarcinoma	en
heal.type	journalArticle	en
heal.identifier.primary	10.1080/02656730110108794	en
heal.identifier.secondary	http://dx.doi.org/10.1080/02656730110108794	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	The aim of this study was to evaluate the potential role of intraoperative hyperthermia (IOHT) in the management of stage IV pancreatic adenocarcinoma. Twenty-seven patients (group A) received pre-operative chemotherapy (5-FU), by-pass surgery with intraoperative bolus infusion of 5-FU and post-operatively multi-agent chemotherapy plus sandostatin and external beam irradiation (45 Gy, 25 fractions, 5 days a week). In a non-randomized way, 10 patients (group B) received an additional single session of IOHT (43-45degreesC, 1 h) performed directly on the tumour using a waveguide applicator (433 MHz) with interstitial measurements of temperature measured. A brief instrument was developed for evaluating patients' quality of life. No progressive disease (PD) was noticed in group B vs 11% (3/27) of PD in group A. There was also a significant increase of overall survival (OS) in group B vs A patients (p = 0.029, log-rank test). Moreover, there was a significant improvement for group B vs A patients regarding Karnofsky performance status (p < 0.001, Mann-Whitney test), pain score (p < 0.001, Mann-Whitney test) and quality of life score (p = 0.031, Mann-Whitney test). A significant correlation was noticed between OS and thermal parameters such as average T-min (p = 0.043), average T-max (p = 0.027) and cumulative minutes T-90 greater than or equal to 44degreesC (p < 0.001). Combined IOHT with chemotherapy (pre-, intra- and post-operative) and external beam post-operative radiotherapy seem to have a potential benefit in the management of unresectable adenocarcinoma of the pancreas, concerning local response, OS and quality of life. Further clinical studies to evaluate the benefit of IOHT suggested in this study are warranted.	en
heal.publisher	TAYLOR & FRANCIS LTD	en
heal.journalName	International Journal of Hyperthermia	en
dc.identifier.doi	10.1080/02656730110108794	en
dc.identifier.isi	ISI:000175620600006	en
dc.identifier.volume	18	en
dc.identifier.issue	3	en
dc.identifier.spage	233	en
dc.identifier.epage	252	en