Novel short-step synthesis of optically active tetronic acids from chiral α-hydroxy acids mediated by 1-hydroxybenzotriazole

Athanasellis, G; Igglessi-Markopoulou, O; Markopoulos, J

dc.contributor.author	Athanasellis, G	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.contributor.author	Markopoulos, J	en
dc.date.accessioned	2014-03-01T01:18:06Z
dc.date.available	2014-03-01T01:18:06Z
dc.date.issued	2002	en
dc.identifier.issn	0936-5214	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14803
dc.subject	γ-hydroxy acids	en
dc.subject	1-hydroxybenzotriazole	en
dc.subject	Natural products	en
dc.subject	Tetronic acids	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	1 hydroxybenzotriazole	en
dc.subject.other	2 hydroxyacid	en
dc.subject.other	3 ethoxycarbonyl 5 phenyltetronic acid	en
dc.subject.other	3 methoxycarbonyl 5 dimethyltetronic acid	en
dc.subject.other	3 methoxycarbonyl 5 phenyltetronic acid	en
dc.subject.other	3 methoxycarbonyltetronic acid	en
dc.subject.other	4 acetoxy 3 hydroxy 2 methoxycarbonyl 4 methyl 2 pentenoate	en
dc.subject.other	benzotriazole derivative	en
dc.subject.other	tetronic acid derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	acylation	en
dc.subject.other	article	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	hydrogenation	en
dc.subject.other	optical rotation	en
dc.subject.other	reaction analysis	en
dc.subject.other	reproducibility	en
dc.title	Novel short-step synthesis of optically active tetronic acids from chiral α-hydroxy acids mediated by 1-hydroxybenzotriazole	en
heal.type	journalArticle	en
heal.identifier.primary	10.1055/s-2002-34248	en
heal.identifier.secondary	http://dx.doi.org/10.1055/s-2002-34248	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	A novel method for the synthesis of functionalized gamma-hydroxy acids and optically active tetronic acids is reported. The synthesis is simple and the compounds are produced in good yields (45-81%). Measurements of their optical rotations show that the reaction proceeds without or with partial racemization of the starting materials.	en
heal.publisher	GEORG THIEME VERLAG KG	en
heal.journalName	Synlett	en
dc.identifier.doi	10.1055/s-2002-34248	en
dc.identifier.isi	ISI:000178555100041	en
dc.identifier.issue	10	en
dc.identifier.spage	1736	en
dc.identifier.epage	1738	en