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One-pot synthesis of chiral N-protected-4-amino functionalized but-2-enoates from α-amino acids mediated by 1-hydroxybenzotriazole

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dc.contributor.author Athanasellis, G en
dc.contributor.author Gavrielatos, E en
dc.contributor.author Igglessi-Markopoulou, O en
dc.date.accessioned 2014-03-01T01:18:10Z
dc.date.available 2014-03-01T01:18:10Z
dc.date.issued 2002 en
dc.identifier.issn 0009-2673 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/14835
dc.subject Amino Acid en
dc.subject.classification Chemistry, Multidisciplinary en
dc.subject.other Liquid chromatography en
dc.subject.other Stereochemistry en
dc.subject.other Synthesis (chemical) en
dc.subject.other One-pot synthesis en
dc.subject.other Amino acids en
dc.subject.other 1 hydroxybenzotriazole en
dc.subject.other 4 acetylamino 2 cyano 3 hydroxybut 2 enoate derivative en
dc.subject.other alpha amino acid en
dc.subject.other benzotriazole derivative en
dc.subject.other unclassified drug en
dc.subject.other article en
dc.subject.other chirality en
dc.subject.other enantiomer en
dc.subject.other high performance liquid chromatography en
dc.subject.other reaction analysis en
dc.subject.other stereochemistry en
dc.subject.other synthesis en
dc.title One-pot synthesis of chiral N-protected-4-amino functionalized but-2-enoates from α-amino acids mediated by 1-hydroxybenzotriazole en
heal.type journalArticle en
heal.identifier.primary 10.1246/bcsj.75.2691 en
heal.identifier.secondary http://dx.doi.org/10.1246/bcsj.75.2691 en
heal.language English en
heal.publicationDate 2002 en
heal.abstract A novel one-pot synthetic route to 4-acetylamino-2-cyano-3-hydroxybut-2-enoates in good yields (63-71%) is reported. An HPLC analysis of these compounds showed very good enantiomeric excesses (90-94%), justifying the success of our methodology to maintain the stereochemical integrity of the starting materials used. en
heal.publisher CHEMICAL SOC JAPAN en
heal.journalName Bulletin of the Chemical Society of Japan en
dc.identifier.doi 10.1246/bcsj.75.2691 en
dc.identifier.isi ISI:000180209100020 en
dc.identifier.volume 75 en
dc.identifier.issue 12 en
dc.identifier.spage 2691 en
dc.identifier.epage 2692 en


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