One-pot synthesis of chiral N-protected-4-amino functionalized but-2-enoates from α-amino acids mediated by 1-hydroxybenzotriazole

Athanasellis, G; Gavrielatos, E; Igglessi-Markopoulou, O

dc.contributor.author	Athanasellis, G	en
dc.contributor.author	Gavrielatos, E	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:18:10Z
dc.date.available	2014-03-01T01:18:10Z
dc.date.issued	2002	en
dc.identifier.issn	0009-2673	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14835
dc.subject	Amino Acid	en
dc.subject.classification	Chemistry, Multidisciplinary	en
dc.subject.other	Liquid chromatography	en
dc.subject.other	Stereochemistry	en
dc.subject.other	Synthesis (chemical)	en
dc.subject.other	One-pot synthesis	en
dc.subject.other	Amino acids	en
dc.subject.other	1 hydroxybenzotriazole	en
dc.subject.other	4 acetylamino 2 cyano 3 hydroxybut 2 enoate derivative	en
dc.subject.other	alpha amino acid	en
dc.subject.other	benzotriazole derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	chirality	en
dc.subject.other	enantiomer	en
dc.subject.other	high performance liquid chromatography	en
dc.subject.other	reaction analysis	en
dc.subject.other	stereochemistry	en
dc.subject.other	synthesis	en
dc.title	One-pot synthesis of chiral N-protected-4-amino functionalized but-2-enoates from α-amino acids mediated by 1-hydroxybenzotriazole	en
heal.type	journalArticle	en
heal.identifier.primary	10.1246/bcsj.75.2691	en
heal.identifier.secondary	http://dx.doi.org/10.1246/bcsj.75.2691	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	A novel one-pot synthetic route to 4-acetylamino-2-cyano-3-hydroxybut-2-enoates in good yields (63-71%) is reported. An HPLC analysis of these compounds showed very good enantiomeric excesses (90-94%), justifying the success of our methodology to maintain the stereochemical integrity of the starting materials used.	en
heal.publisher	CHEMICAL SOC JAPAN	en
heal.journalName	Bulletin of the Chemical Society of Japan	en
dc.identifier.doi	10.1246/bcsj.75.2691	en
dc.identifier.isi	ISI:000180209100020	en
dc.identifier.volume	75	en
dc.identifier.issue	12	en
dc.identifier.spage	2691	en
dc.identifier.epage	2692	en