Release of propranolol and diclofenac from low Mw DL-poly(lactic acid)

Mamouzelos, NJ; Proikakis, CS; Tarantili, PA; Andreopoulos, AG

dc.contributor.author	Mamouzelos, NJ	en
dc.contributor.author	Proikakis, CS	en
dc.contributor.author	Tarantili, PA	en
dc.contributor.author	Andreopoulos, AG	en
dc.date.accessioned	2014-03-01T01:18:17Z
dc.date.available	2014-03-01T01:18:17Z
dc.date.issued	2002	en
dc.identifier.issn	0885-3282	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14921
dc.subject	Biodegradable systems	en
dc.subject	Controlled release	en
dc.subject	Diclofenac	en
dc.subject	DL-poly(lactic acid)	en
dc.subject	Propranolol	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Materials Science, Biomaterials	en
dc.subject.other	Biodegradation	en
dc.subject.other	Biomaterials	en
dc.subject.other	Biomedical engineering	en
dc.subject.other	Molecular weight	en
dc.subject.other	Organic polymers	en
dc.subject.other	Polymerization	en
dc.subject.other	Ultraviolet spectroscopy	en
dc.subject.other	Biodegradable systems	en
dc.subject.other	Controlled release	en
dc.subject.other	Diclofenac	en
dc.subject.other	Polylactic acid	en
dc.subject.other	Propanolol	en
dc.subject.other	Controlled drug delivery	en
dc.subject.other	biomaterial	en
dc.subject.other	diclofenac	en
dc.subject.other	drug carrier	en
dc.subject.other	lactic acid	en
dc.subject.other	polylactic acid	en
dc.subject.other	polymer	en
dc.subject.other	propranolol	en
dc.subject.other	article	en
dc.subject.other	chemistry	en
dc.subject.other	delayed release formulation	en
dc.subject.other	differential scanning calorimetry	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	molecular weight	en
dc.subject.other	pH	en
dc.subject.other	viscosity	en
dc.subject.other	Biocompatible Materials	en
dc.subject.other	Calorimetry, Differential Scanning	en
dc.subject.other	Delayed-Action Preparations	en
dc.subject.other	Diclofenac	en
dc.subject.other	Drug Carriers	en
dc.subject.other	Hydrogen-Ion Concentration	en
dc.subject.other	Lactic Acid	en
dc.subject.other	Molecular Weight	en
dc.subject.other	Polymers	en
dc.subject.other	Propranolol	en
dc.subject.other	Spectroscopy, Fourier Transform Infrared	en
dc.subject.other	Viscosity	en
dc.title	Release of propranolol and diclofenac from low Mw DL-poly(lactic acid)	en
heal.type	journalArticle	en
heal.identifier.primary	10.1177/0885328202016003174	en
heal.identifier.secondary	http://dx.doi.org/10.1177/0885328202016003174	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	The controlled release of two drugs, i.e. the sodium salt of diclofenac and propranolol was studied, by using low molecular weight D,L-Poly(lactic acid) as a matrix. Tablets of the above polymer containing those drugs were immersed into buffers with various pH values and delivery was recorded as a function of time, via UV-spectroscopy. The results showed that the polymer is appropriate for such biomedical applications, as generally, it ensures complete drug delivery within 45-60 days, which is acceptable for most cases. On the other hand, the release rate depends on many parameters including the interactions among drug, matrix and the surrounding liquid, which adds complexity to the process and requires careful investigation for proper design of a controlled release system.	en
heal.publisher	SAGE PUBLICATIONS LTD	en
heal.journalName	Journal of Biomaterials Applications	en
dc.identifier.doi	10.1177/0885328202016003174	en
dc.identifier.isi	ISI:000174587100001	en
dc.identifier.volume	16	en
dc.identifier.issue	3	en
dc.identifier.spage	177	en
dc.identifier.epage	190	en