HEAL DSpace

Release of propranolol and diclofenac from low Mw DL-poly(lactic acid)

Αποθετήριο DSpace/Manakin

Εμφάνιση απλής εγγραφής

dc.contributor.author Mamouzelos, NJ en
dc.contributor.author Proikakis, CS en
dc.contributor.author Tarantili, PA en
dc.contributor.author Andreopoulos, AG en
dc.date.accessioned 2014-03-01T01:18:17Z
dc.date.available 2014-03-01T01:18:17Z
dc.date.issued 2002 en
dc.identifier.issn 0885-3282 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/14921
dc.subject Biodegradable systems en
dc.subject Controlled release en
dc.subject Diclofenac en
dc.subject DL-poly(lactic acid) en
dc.subject Propranolol en
dc.subject.classification Engineering, Biomedical en
dc.subject.classification Materials Science, Biomaterials en
dc.subject.other Biodegradation en
dc.subject.other Biomaterials en
dc.subject.other Biomedical engineering en
dc.subject.other Molecular weight en
dc.subject.other Organic polymers en
dc.subject.other Polymerization en
dc.subject.other Ultraviolet spectroscopy en
dc.subject.other Biodegradable systems en
dc.subject.other Controlled release en
dc.subject.other Diclofenac en
dc.subject.other Polylactic acid en
dc.subject.other Propanolol en
dc.subject.other Controlled drug delivery en
dc.subject.other biomaterial en
dc.subject.other diclofenac en
dc.subject.other drug carrier en
dc.subject.other lactic acid en
dc.subject.other polylactic acid en
dc.subject.other polymer en
dc.subject.other propranolol en
dc.subject.other article en
dc.subject.other chemistry en
dc.subject.other delayed release formulation en
dc.subject.other differential scanning calorimetry en
dc.subject.other infrared spectroscopy en
dc.subject.other molecular weight en
dc.subject.other pH en
dc.subject.other viscosity en
dc.subject.other Biocompatible Materials en
dc.subject.other Calorimetry, Differential Scanning en
dc.subject.other Delayed-Action Preparations en
dc.subject.other Diclofenac en
dc.subject.other Drug Carriers en
dc.subject.other Hydrogen-Ion Concentration en
dc.subject.other Lactic Acid en
dc.subject.other Molecular Weight en
dc.subject.other Polymers en
dc.subject.other Propranolol en
dc.subject.other Spectroscopy, Fourier Transform Infrared en
dc.subject.other Viscosity en
dc.title Release of propranolol and diclofenac from low Mw DL-poly(lactic acid) en
heal.type journalArticle en
heal.identifier.primary 10.1177/0885328202016003174 en
heal.identifier.secondary http://dx.doi.org/10.1177/0885328202016003174 en
heal.language English en
heal.publicationDate 2002 en
heal.abstract The controlled release of two drugs, i.e. the sodium salt of diclofenac and propranolol was studied, by using low molecular weight D,L-Poly(lactic acid) as a matrix. Tablets of the above polymer containing those drugs were immersed into buffers with various pH values and delivery was recorded as a function of time, via UV-spectroscopy. The results showed that the polymer is appropriate for such biomedical applications, as generally, it ensures complete drug delivery within 45-60 days, which is acceptable for most cases. On the other hand, the release rate depends on many parameters including the interactions among drug, matrix and the surrounding liquid, which adds complexity to the process and requires careful investigation for proper design of a controlled release system. en
heal.publisher SAGE PUBLICATIONS LTD en
heal.journalName Journal of Biomaterials Applications en
dc.identifier.doi 10.1177/0885328202016003174 en
dc.identifier.isi ISI:000174587100001 en
dc.identifier.volume 16 en
dc.identifier.issue 3 en
dc.identifier.spage 177 en
dc.identifier.epage 190 en


Αρχεία σε αυτό το τεκμήριο

Αρχεία Μέγεθος Μορφότυπο Προβολή

Δεν υπάρχουν αρχεία που σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στην ακόλουθη συλλογή(ές)

Εμφάνιση απλής εγγραφής