Study of biopolymers as carriers for controlled release

Andreopoulos, AG; Tarantili, PA

dc.contributor.author	Andreopoulos, AG	en
dc.contributor.author	Tarantili, PA	en
dc.date.accessioned	2014-03-01T01:18:22Z
dc.date.available	2014-03-01T01:18:22Z
dc.date.issued	2002	en
dc.identifier.issn	0022-2348	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14964
dc.subject	Controlled release	en
dc.subject	Diffusion	en
dc.subject	Erosion	en
dc.subject	Hydroxypropylmethyl cellulose	en
dc.subject	Swelling	en
dc.subject	Xanthan gum	en
dc.subject.classification	Polymer Science	en
dc.subject.other	Diffusion in solids	en
dc.subject.other	Dissolution	en
dc.subject.other	Mixtures	en
dc.subject.other	Polysaccharides	en
dc.subject.other	Swelling	en
dc.subject.other	Controlled release	en
dc.subject.other	Fickian diffusion	en
dc.subject.other	Hydroxypropylmethyl cellulose	en
dc.subject.other	Salicylic acid	en
dc.subject.other	Xanthan gum	en
dc.subject.other	Biopolymers	en
dc.title	Study of biopolymers as carriers for controlled release	en
heal.type	journalArticle	en
heal.identifier.primary	10.1081/MB-120004353	en
heal.identifier.secondary	http://dx.doi.org/10.1081/MB-120004353	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	An attempt was made to compare swelling and release behavior of two polysaccharides, xanthan gum (XG) and hydroxypropylmethyl cellulose (HPMC), taking into consideration their dissolution characteristics. This study was expected to provide information about the capability of these polymers to satisfy specific requirements in the design of controlled release systems. Tablets were prepared from the pure polymers as well as by using mixtures of XG and HPMC containing 1, 2, and 5% salicylic acid (SA) as a model drug. Swelling and dissolution experiments were run and the release in distilled water was recorded as a function of time. The results showed that XG and HPMC are very interesting matrices for the preparation of controlled release systems. Complete administration of SA in concentrations from 1 to 5% takes place within about 10 hr for XG, whereas approximately 5 days are necessary for the same result in the case of HPMC tablets. For both systems, nonFickian behavior was recorded with the diffusion exponent ranging from 0.67 to 0.78. Upon fitting the release data to the Peppas and Sahlin heuristic model, it was clear that, in general, erosion was the predominant factor for SA release from XG tablets, whereas the acid delivery from HPMC mainly proceeds via Fickian diffusion. These results seemed to be dependent on the water solubility of the released substance.	en
heal.publisher	MARCEL DEKKER INC	en
heal.journalName	Journal of Macromolecular Science - Physics	en
dc.identifier.doi	10.1081/MB-120004353	en
dc.identifier.isi	ISI:000176590500009	en
dc.identifier.volume	41 B	en
dc.identifier.issue	3	en
dc.identifier.spage	559	en
dc.identifier.epage	578	en