Synthesis of tetronic acid derivatives from novel active esters of α-hydroxyacids

Mitsos, C; Zografos, A; Igglessi-Markopoulou, O

dc.contributor.author	Mitsos, C	en
dc.contributor.author	Zografos, A	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:18:23Z
dc.date.available	2014-03-01T01:18:23Z
dc.date.issued	2002	en
dc.identifier.issn	0022-152X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/14977
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	2 acetoxyphenylacetic acid	en
dc.subject.other	2 hydroxyacid	en
dc.subject.other	5 phenyltetronic acid derivative	en
dc.subject.other	beta,beta' tricarbonyl derivative	en
dc.subject.other	carbene	en
dc.subject.other	carbonyl derivative	en
dc.subject.other	ester	en
dc.subject.other	n hydroxysuccinimide	en
dc.subject.other	phenylacetic acid derivative	en
dc.subject.other	succinimide derivative	en
dc.subject.other	tetronic acid derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	cyclization	en
dc.subject.other	deprotection reaction	en
dc.subject.other	drug synthesis	en
dc.subject.other	optics	en
dc.subject.other	polymerization	en
dc.title	Synthesis of tetronic acid derivatives from novel active esters of α-hydroxyacids	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/jhet.5570390614	en
heal.identifier.secondary	http://dx.doi.org/10.1002/jhet.5570390614	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	Active esters, produced by condensation of O-acetyl protected alpha-hydroxyacids with N-hydroxysuccinimide, react with anions of active methylene compounds to afford beta,beta'-tricarbonyl derivatives which upon deprotection undergo cyclization to 3-alkoxycarbonyl and 3-acyl tetronic acids. Incorporation of (S)-2-acetoxyphenylacetic acid in this reaction sequence enables the synthesis of optically active 5-phenyltetronic acid derivatives.	en
heal.publisher	HETERO CORPORATION	en
heal.journalName	Journal of Heterocyclic Chemistry	en
dc.identifier.doi	10.1002/jhet.5570390614	en
dc.identifier.isi	ISI:000180476400014	en
dc.identifier.volume	39	en
dc.identifier.issue	6	en
dc.identifier.spage	1201	en
dc.identifier.epage	1205	en