Use of image processing techniques to assess effect of disodium pamidronate in conjunction with radiotherapy in patients with bone metastases

Kouloulias, VE; Dardoufas, CE; Kouvaris, JR; Antypas, CE; Sandilos, PH; Matsopoulos, GK; Vlahos, LJ

dc.contributor.author	Kouloulias, VE	en
dc.contributor.author	Dardoufas, CE	en
dc.contributor.author	Kouvaris, JR	en
dc.contributor.author	Antypas, CE	en
dc.contributor.author	Sandilos, PH	en
dc.contributor.author	Matsopoulos, GK	en
dc.contributor.author	Vlahos, LJ	en
dc.date.accessioned	2014-03-01T01:18:27Z
dc.date.available	2014-03-01T01:18:27Z
dc.date.issued	2002	en
dc.identifier.issn	0284-186X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15024
dc.subject	Bone Metastases	en
dc.subject	Image Processing Techniques	en
dc.subject.classification	Oncology	en
dc.subject.other	BREAST-CANCER	en
dc.subject.other	BISPHOSPHONATES	en
dc.subject.other	DISEASE	en
dc.subject.other	DENSITY	en
dc.subject.other	TRIAL	en
dc.title	Use of image processing techniques to assess effect of disodium pamidronate in conjunction with radiotherapy in patients with bone metastases	en
heal.type	journalArticle	en
heal.identifier.primary	10.1080/028418602753669553	en
heal.identifier.secondary	http://dx.doi.org/10.1080/028418602753669553	en
heal.language	English	en
heal.publicationDate	2002	en
heal.abstract	The aim of this study was radiographically to monitor the effect of disodium pamidronate on metastatic bone disease, using image-processing techniques. Eighteen patients with osteolytic metastases from breast cancer received an intravenous infusion of 180 mg disodium pamidronate every 4 weeks for a period of 6 months. The first session of intravenous infusions was given concurrently with external beam radiotherapy with a 6 MV linear accelerator (total dose 30 Gy in 10 fractions). Radiographs of osteolytic lesions were obtained at every session of the treatment, retaining the same settings for each modality. The analysis of the attributes of the images was based on measuring the first-order statistics of the gray-level histogram in terms of mean value (MVGLH) and energy (EGLH). The measurements showed significant differences for MVGLH and EGLH values (p < 0.05, Wilcoxon test). Analytically, there was an 11.08% (95% CI = 10.21, 11.93) mean reduction of EGLH and an 11.63% (95% CI = 10.96, 12.29) mean increase of MVGLH of the x-ray images, before and after the combined treatment protocol. The changes in the image-processing indices were also highly correlated with the reduction of the patient's pain score. These findings indicate an important increase in bone mass and bone formation, which the radiologists found difficult to identify visually.	en
heal.publisher	TAYLOR & FRANCIS AS	en
heal.journalName	ACTA ONCOLOGICA	en
dc.identifier.doi	10.1080/028418602753669553	en
dc.identifier.isi	ISI:000175951000010	en
dc.identifier.volume	41	en
dc.identifier.issue	2	en
dc.identifier.spage	169	en
dc.identifier.epage	174	en