HEAL DSpace

A geometry based optimization algorithm for conformal external beam radiotherapy

Αποθετήριο DSpace/Manakin

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dc.contributor.author Schreibmann, E en
dc.contributor.author Lahanas, M en
dc.contributor.author Uricchio, R en
dc.contributor.author Theodorou, K en
dc.contributor.author Kappas, C en
dc.contributor.author Baltas, D en
dc.date.accessioned 2014-03-01T01:18:31Z
dc.date.available 2014-03-01T01:18:31Z
dc.date.issued 2003 en
dc.identifier.issn 0031-9155 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/15063
dc.subject.classification Engineering, Biomedical en
dc.subject.classification Radiology, Nuclear Medicine & Medical Imaging en
dc.subject.other Algorithms en
dc.subject.other Biological organs en
dc.subject.other Dosimetry en
dc.subject.other Optimization en
dc.subject.other Tumors en
dc.subject.other Collimators en
dc.subject.other Radiotherapy en
dc.subject.other algorithm en
dc.subject.other article en
dc.subject.other collimator en
dc.subject.other controlled study en
dc.subject.other correlation analysis en
dc.subject.other dosimetry en
dc.subject.other geometry en
dc.subject.other head tumor en
dc.subject.other human en
dc.subject.other intermethod comparison en
dc.subject.other male en
dc.subject.other organ en
dc.subject.other priority journal en
dc.subject.other prostate cancer en
dc.subject.other radiation beam en
dc.subject.other radiation dose en
dc.subject.other radiation dose distribution en
dc.subject.other radiation exposure en
dc.subject.other treatment planning en
dc.subject.other Algorithms en
dc.subject.other Biophysics en
dc.subject.other Brain Neoplasms en
dc.subject.other Humans en
dc.subject.other Male en
dc.subject.other Phantoms, Imaging en
dc.subject.other Prostatic Neoplasms en
dc.subject.other Radiotherapy Planning, Computer-Assisted en
dc.subject.other Radiotherapy, Conformal en
dc.title A geometry based optimization algorithm for conformal external beam radiotherapy en
heal.type journalArticle en
heal.identifier.primary 10.1088/0031-9155/48/12/311 en
heal.identifier.secondary http://dx.doi.org/10.1088/0031-9155/48/12/311 en
heal.language English en
heal.publicationDate 2003 en
heal.abstract A geometric solution of the problem of optimal orientation of beams in conformal external radiotherapy is presented. The method uses geometric derived quantities which consider the intersection volume between organs at risk (OAR) and the beam shape. In comparison to previous geometric methods a true 3D volume computation is used which takes into account beam divergence, concave shapes, as well as treatment settings such as individual beam shaping by blocks or multi-leaf collimators. For standard dosimetric cost functions used by dose optimization algorithms a corresponding set of geometric objective functions is proposed. We compare the correlations between geometric and dosimetric cost functions for two clinical cases, a prostate and a head tumour case. A correlation is observed for the prostate case, whereas for the head case it is less pronounced due to the larger part of overlapping volumes between the beams which cannot be considered by the used objectives. In comparison to not-optimized beam directions the dose distribution is significantly better for the beam directions found by the optimization of a geometric multi-objective cost function. An optimal dose distribution can easily be achieved using the geometric model. This is shown by comparing for the two cases the dose-volume histograms (DVH) of manually optimized plans by experienced planners and the DVHs of the geometrically found optimal solutions. In comparison to the manually optimized plans the solutions found by the geometric method significantly reduce the average dose in the OARs and NT, while maintaining the same PTV coverage. en
heal.publisher IOP PUBLISHING LTD en
heal.journalName Physics in Medicine and Biology en
dc.identifier.doi 10.1088/0031-9155/48/12/311 en
dc.identifier.isi ISI:000184063200011 en
dc.identifier.volume 48 en
dc.identifier.issue 12 en
dc.identifier.spage 1825 en
dc.identifier.epage 1841 en


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