An efficient route to 3-aryl-substituted quinolin-2-one and 1,8-naphthyridin-2-one derivatives of pharmaceutical interest

Mitsos, CA; Zografos, AL; Igglessi-Markopoulou, O

dc.contributor.author	Mitsos, CA	en
dc.contributor.author	Zografos, AL	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:18:38Z
dc.date.available	2014-03-01T01:18:38Z
dc.date.issued	2003	en
dc.identifier.issn	0022-3263	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15121
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	Cyclization	en
dc.subject.other	Derivatives	en
dc.subject.other	Drug products	en
dc.subject.other	Esters	en
dc.subject.other	Ketones	en
dc.subject.other	Reaction kinetics	en
dc.subject.other	Synthesis (chemical)	en
dc.subject.other	Aromatic compounds	en
dc.subject.other	1 acyl 4 hydroxy 1,8 naphthyridine 2(1h) one derivative	en
dc.subject.other	4 hydroxyquinolin 2(1h) one derivative	en
dc.subject.other	n methyl dextro aspartic acid receptor	en
dc.subject.other	naphthyridine derivative	en
dc.subject.other	quinoline derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	cyclization	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	endocrine disease	en
dc.subject.other	osteoporosis	en
dc.subject.other	reaction analysis	en
dc.subject.other	structure analysis	en
dc.subject.other	Catalysis	en
dc.subject.other	Indicators and Reagents	en
dc.subject.other	Molecular Structure	en
dc.subject.other	Naphthyridines	en
dc.subject.other	Oxazines	en
dc.subject.other	Pharmaceutical Preparations	en
dc.subject.other	Quinolones	en
dc.title	An efficient route to 3-aryl-substituted quinolin-2-one and 1,8-naphthyridin-2-one derivatives of pharmaceutical interest	en
heal.type	journalArticle	en
heal.identifier.primary	10.1021/jo0340051	en
heal.identifier.secondary	http://dx.doi.org/10.1021/jo0340051	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	Reaction of arylacetic ester enolates with 2-alkoxy-4H-3,1-benzoxazin-4-ones offers a short and versatile synthetic route to 3-aryl-4-hydroxyquinolin-2(1H)-ones, through the cyclization of the beta-ketoesters produced. Similar reactions of 4H-pyrido[2,3-d][1,3]oxazin-4-ones with ester enolates afford 1-acyl-4-hydroxy-1,8-naphthyridin-2(1H)-ones in a convenient two-step, one-pot procedure.	en
heal.publisher	AMER CHEMICAL SOC	en
heal.journalName	Journal of Organic Chemistry	en
dc.identifier.doi	10.1021/jo0340051	en
dc.identifier.isi	ISI:000183066100063	en
dc.identifier.volume	68	en
dc.identifier.issue	11	en
dc.identifier.spage	4567	en
dc.identifier.epage	4569	en