An efficient synthesis of 2-amino-3-cyano-2-pyrrolin-4-ones, via the corresponding open chain tautomers (aminoacetylmalononitriles)

Hamilakis, S; Tsolomitis, A

dc.contributor.author	Hamilakis, S	en
dc.contributor.author	Tsolomitis, A	en
dc.date.accessioned	2014-03-01T01:18:38Z
dc.date.available	2014-03-01T01:18:38Z
dc.date.issued	2003	en
dc.identifier.issn	0040-4039	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15122
dc.subject	2-amino-3-cyano-2-pyrrolin-4-ones	en
dc.subject	Aminoacetylmalononitriles	en
dc.subject	CDI	en
dc.subject	Tautomers	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	2 amino 3 cyano 2 pyrrolin 4 one	en
dc.subject.other	amino acid	en
dc.subject.other	aminoacetonitrile	en
dc.subject.other	aminoacetylmalononitrile	en
dc.subject.other	carbene	en
dc.subject.other	carbonyl derivative	en
dc.subject.other	carbonyl diimidazole	en
dc.subject.other	chemical compound	en
dc.subject.other	enol	en
dc.subject.other	glycine derivative	en
dc.subject.other	imidazole derivative	en
dc.subject.other	malononitrile	en
dc.subject.other	prodrug	en
dc.subject.other	unclassified drug	en
dc.subject.other	acylation	en
dc.subject.other	article	en
dc.subject.other	chemical parameters	en
dc.subject.other	chemical procedures	en
dc.subject.other	drug synthesis	en
dc.subject.other	isolation procedure	en
dc.title	An efficient synthesis of 2-amino-3-cyano-2-pyrrolin-4-ones, via the corresponding open chain tautomers (aminoacetylmalononitriles)	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/S0040-4039(03)00730-5	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0040-4039(03)00730-5	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	Malononitrile has been found to be acylated effectively using N-protected glycines by simultaneous activation of an amino acid carbonyl group and a malononitrile methylene group using carbonyl diimidazole (CDI). The corresponding aminoacetonitriles were isolated as enols and/or as their tautomeric forms, 2-amino-3-cyano-2-pyrrolin-4-ones. (C) 2003 Elsevier Science Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Tetrahedron Letters	en
dc.identifier.doi	10.1016/S0040-4039(03)00730-5	en
dc.identifier.isi	ISI:000182573300022	en
dc.identifier.volume	44	en
dc.identifier.issue	19	en
dc.identifier.spage	3821	en
dc.identifier.epage	3823	en