HEAL DSpace

Do atypical antipsychotics fail to exert cognitive sparing effects?

Αποθετήριο DSpace/Manakin

Εμφάνιση απλής εγγραφής

dc.contributor.author Papageorgiou, C en
dc.contributor.author Oulis, P en
dc.contributor.author Vasios, C en
dc.contributor.author Matsopoulos, GK en
dc.contributor.author Uzunoglu, N en
dc.contributor.author Rabavilas, A en
dc.contributor.author Christodoulou, GN en
dc.date.accessioned 2014-03-01T01:18:53Z
dc.date.available 2014-03-01T01:18:53Z
dc.date.issued 2003 en
dc.identifier.issn 0959-4965 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/15247
dc.subject Atypical antipsychotics en
dc.subject Auditory hallucinations en
dc.subject Clozapine en
dc.subject Olanzapine en
dc.subject P600 en
dc.subject Working memory en
dc.subject.classification Neurosciences en
dc.subject.other clozapine en
dc.subject.other neuroleptic agent en
dc.subject.other olanzapine en
dc.subject.other adult en
dc.subject.other article en
dc.subject.other auditory hallucination en
dc.subject.other clinical article en
dc.subject.other cognition en
dc.subject.other controlled study en
dc.subject.other event related potential en
dc.subject.other human en
dc.subject.other male en
dc.subject.other memory en
dc.subject.other priority journal en
dc.subject.other schizophrenia en
dc.subject.other working memory en
dc.subject.other Adult en
dc.subject.other Antipsychotic Agents en
dc.subject.other Benzodiazepines en
dc.subject.other Brain en
dc.subject.other Clozapine en
dc.subject.other Cognition en
dc.subject.other Double-Blind Method en
dc.subject.other Evoked Potentials, Auditory en
dc.subject.other Hallucinations en
dc.subject.other Humans en
dc.subject.other Male en
dc.subject.other Memory en
dc.subject.other Pirenzepine en
dc.subject.other Psychiatric Status Rating Scales en
dc.subject.other Reference Values en
dc.subject.other Schizophrenia en
dc.subject.other Schizophrenic Psychology en
dc.title Do atypical antipsychotics fail to exert cognitive sparing effects? en
heal.type journalArticle en
heal.identifier.primary 10.1097/00001756-200303030-00042 en
heal.identifier.secondary http://dx.doi.org/10.1097/00001756-200303030-00042 en
heal.language English en
heal.publicationDate 2003 en
heal.abstract The aim of the study was to investigate patterns of the P600 component of event-related potentials (ERPs) elicited during a working memory test in 16 male schizophrenic patients experiencing auditory hallucinations before and after treatment with clozapine and olanzapine, and 13 male normal subjects matched for age and educational level. Before treatment, patients showed significantly reduced P600 amplitudes on the right parietal region compared with controls, and when in remission also showed significantly reduced P600 amplitudes located on the right parietal and temporofrontal areas, compared both to themselves before treatment and to normal controls. The patient's memory performance before and after treatment remained significantly lower than that of healthy controls. These findings may indicate that auditory hallucinations in schizophrenia are associated with impaired synchronization of the processes related to target detection, as reflected by the P600. The present study also casts doubts regarding the cognitive sparing effect of atypical antipsychotics, despite the fact that they mediate symptom improvement. © 2003 Lippincott Williams & Wilkins. en
heal.publisher LIPPINCOTT WILLIAMS & WILKINS en
heal.journalName NeuroReport en
dc.identifier.doi 10.1097/00001756-200303030-00042 en
dc.identifier.isi ISI:000181641800042 en
dc.identifier.volume 14 en
dc.identifier.issue 3 en
dc.identifier.spage 505 en
dc.identifier.epage 509 en


Αρχεία σε αυτό το τεκμήριο

Αρχεία Μέγεθος Μορφότυπο Προβολή

Δεν υπάρχουν αρχεία που σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στην ακόλουθη συλλογή(ές)

Εμφάνιση απλής εγγραφής