Do atypical antipsychotics fail to exert cognitive sparing effects?

Papageorgiou, C; Oulis, P; Vasios, C; Matsopoulos, GK; Uzunoglu, N; Rabavilas, A; Christodoulou, GN

dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Oulis, P	en
dc.contributor.author	Vasios, C	en
dc.contributor.author	Matsopoulos, GK	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Rabavilas, A	en
dc.contributor.author	Christodoulou, GN	en
dc.date.accessioned	2014-03-01T01:18:53Z
dc.date.available	2014-03-01T01:18:53Z
dc.date.issued	2003	en
dc.identifier.issn	0959-4965	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15247
dc.subject	Atypical antipsychotics	en
dc.subject	Auditory hallucinations	en
dc.subject	Clozapine	en
dc.subject	Olanzapine	en
dc.subject	P600	en
dc.subject	Working memory	en
dc.subject.classification	Neurosciences	en
dc.subject.other	clozapine	en
dc.subject.other	neuroleptic agent	en
dc.subject.other	olanzapine	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	auditory hallucination	en
dc.subject.other	clinical article	en
dc.subject.other	cognition	en
dc.subject.other	controlled study	en
dc.subject.other	event related potential	en
dc.subject.other	human	en
dc.subject.other	male	en
dc.subject.other	memory	en
dc.subject.other	priority journal	en
dc.subject.other	schizophrenia	en
dc.subject.other	working memory	en
dc.subject.other	Adult	en
dc.subject.other	Antipsychotic Agents	en
dc.subject.other	Benzodiazepines	en
dc.subject.other	Brain	en
dc.subject.other	Clozapine	en
dc.subject.other	Cognition	en
dc.subject.other	Double-Blind Method	en
dc.subject.other	Evoked Potentials, Auditory	en
dc.subject.other	Hallucinations	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Memory	en
dc.subject.other	Pirenzepine	en
dc.subject.other	Psychiatric Status Rating Scales	en
dc.subject.other	Reference Values	en
dc.subject.other	Schizophrenia	en
dc.subject.other	Schizophrenic Psychology	en
dc.title	Do atypical antipsychotics fail to exert cognitive sparing effects?	en
heal.type	journalArticle	en
heal.identifier.primary	10.1097/00001756-200303030-00042	en
heal.identifier.secondary	http://dx.doi.org/10.1097/00001756-200303030-00042	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	The aim of the study was to investigate patterns of the P600 component of event-related potentials (ERPs) elicited during a working memory test in 16 male schizophrenic patients experiencing auditory hallucinations before and after treatment with clozapine and olanzapine, and 13 male normal subjects matched for age and educational level. Before treatment, patients showed significantly reduced P600 amplitudes on the right parietal region compared with controls, and when in remission also showed significantly reduced P600 amplitudes located on the right parietal and temporofrontal areas, compared both to themselves before treatment and to normal controls. The patient's memory performance before and after treatment remained significantly lower than that of healthy controls. These findings may indicate that auditory hallucinations in schizophrenia are associated with impaired synchronization of the processes related to target detection, as reflected by the P600. The present study also casts doubts regarding the cognitive sparing effect of atypical antipsychotics, despite the fact that they mediate symptom improvement. © 2003 Lippincott Williams & Wilkins.	en
heal.publisher	LIPPINCOTT WILLIAMS & WILKINS	en
heal.journalName	NeuroReport	en
dc.identifier.doi	10.1097/00001756-200303030-00042	en
dc.identifier.isi	ISI:000181641800042	en
dc.identifier.volume	14	en
dc.identifier.issue	3	en
dc.identifier.spage	505	en
dc.identifier.epage	509	en