Monte Carlo dosimetry of a new 192Ir pulsed dose rate brachytherapy source

Karaiskos, P; Angelopoulos, A; Pantelis, E; Papagiannis, P; Sakelliou, L; Kouwenhoven, E; Baltas, D

dc.contributor.author	Karaiskos, P	en
dc.contributor.author	Angelopoulos, A	en
dc.contributor.author	Pantelis, E	en
dc.contributor.author	Papagiannis, P	en
dc.contributor.author	Sakelliou, L	en
dc.contributor.author	Kouwenhoven, E	en
dc.contributor.author	Baltas, D	en
dc.date.accessioned	2014-03-01T01:19:18Z
dc.date.available	2014-03-01T01:19:18Z
dc.date.issued	2003	en
dc.identifier.issn	0094-2405	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15406
dc.subject	192Ir	en
dc.subject	Brachytherapy	en
dc.subject	Dosimetry	en
dc.subject	Monte Carlo	en
dc.subject	PDR	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	iridium 192	en
dc.subject.other	water	en
dc.subject.other	air	en
dc.subject.other	anisotropy	en
dc.subject.other	article	en
dc.subject.other	brachytherapy	en
dc.subject.other	dose calculation	en
dc.subject.other	dosimetry	en
dc.subject.other	geometry	en
dc.subject.other	mathematical analysis	en
dc.subject.other	Monte Carlo method	en
dc.subject.other	phantom	en
dc.subject.other	photon	en
dc.subject.other	priority journal	en
dc.subject.other	pulsed dose rate brachytherapy	en
dc.subject.other	radiation dose	en
dc.subject.other	Anisotropy	en
dc.subject.other	Brachytherapy	en
dc.subject.other	Humans	en
dc.subject.other	Iridium Radioisotopes	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Phantoms, Imaging	en
dc.subject.other	Quality Control	en
dc.subject.other	Radiometry	en
dc.subject.other	Radiopharmaceuticals	en
dc.subject.other	Radiotherapy Dosage	en
dc.subject.other	Radiotherapy Planning, Computer-Assisted	en
dc.subject.other	Sensitivity and Specificity	en
dc.title	Monte Carlo dosimetry of a new 192Ir pulsed dose rate brachytherapy source	en
heal.type	journalArticle	en
heal.identifier.primary	10.1118/1.1524168	en
heal.identifier.secondary	http://dx.doi.org/10.1118/1.1524168	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	A new microSelectron pulsed dose rate source has been designed, containing two active pellets instead of one inactive and one active pellet contained in the old design, to facilitate the incorporation of higher activity up to 74 GBq (2 Ci). In this work, Monte Carlo simulation is used to derive full dosimetric data following the AAPM TG-43 formalism, as well as the dose rate. per unit air kerma strength data in Cartesian, "away and along" coordinates for both source designs. The calculated dose rate constant of the new PDR source design was found equal to Lambda=(1.121 +/- 0.006) cGyh(-1)U(-1) compared to Lambda=(1.124+/-0.006) cGy h(-1)U(-1) forthe old design. Radial dose functions of the two sources calculated using the point source approximated geometry factors were found in close agreement (within 1%) except for radial distances under 2 mm. At polar angles close to the longitudinal source axis at the sources' distal end, the new design presents increased anisotropy (up to 10%) compared to the old one due to its longer active core. At polar angles close to the longitudinal source axis at the sources' drive wire end however, the old design presents increased anisotropy (up to 18%) due to attenuation of emitted photons through the inactive Ir pellet. These differences, also present in "away and along" dose rate results, necessitate the replacement of treatment planning input data for the new microSelectron pulsed dose rate source. (C) 2003 American Association of Physicists in Medicine.	en
heal.publisher	AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS	en
heal.journalName	Medical Physics	en
dc.identifier.doi	10.1118/1.1524168	en
dc.identifier.isi	ISI:000180493600002	en
dc.identifier.volume	30	en
dc.identifier.issue	1	en
dc.identifier.spage	9	en
dc.identifier.epage	16	en