Nucleophilic Ring Enlargement of 2-Substituted-3-isothiazolones to 1,3-Thiazin-4-ones

Hamilakis, S; Tsolomitis, A

dc.contributor.author	Hamilakis, S	en
dc.contributor.author	Tsolomitis, A	en
dc.date.accessioned	2014-03-01T01:19:20Z
dc.date.available	2014-03-01T01:19:20Z
dc.date.issued	2003	en
dc.identifier.issn	0039-7911	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15433
dc.subject	1,3-Thiazin-4-ones	en
dc.subject	3-Isothiazolones	en
dc.subject	Nucleophilic ring expansion	en
dc.subject	Two phase reactions	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	1,3 thiazin 4 one derivative	en
dc.subject.other	1,3 thiazine derivative	en
dc.subject.other	3 isothiazolone derivative	en
dc.subject.other	amine	en
dc.subject.other	isothiazolone derivative	en
dc.subject.other	nitrogen	en
dc.subject.other	sulfur	en
dc.subject.other	thiazole derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	aqueous solution	en
dc.subject.other	article	en
dc.subject.other	chemical analysis	en
dc.subject.other	chemical bond	en
dc.subject.other	chemical reaction	en
dc.subject.other	conformational transition	en
dc.subject.other	dissociation	en
dc.subject.other	drug conformation	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	proton nuclear magnetic resonance	en
dc.subject.other	proton transport	en
dc.subject.other	reaction analysis	en
dc.subject.other	room temperature	en
dc.subject.other	structure analysis	en
dc.subject.other	substitution reaction	en
dc.subject.other	technique	en
dc.title	Nucleophilic Ring Enlargement of 2-Substituted-3-isothiazolones to 1,3-Thiazin-4-ones	en
heal.type	journalArticle	en
heal.identifier.primary	10.1081/SCC-120026864	en
heal.identifier.secondary	http://dx.doi.org/10.1081/SCC-120026864	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	1,3-Thiazin-4-ones 9 and 10 have been prepared from the corresponding isothiazolones 7 and 8 by a clean and smooth reaction with tertiary amines at room temperature. This rearrangement is attributed to the abstraction of a methine proton from the 2-position isothiazolone substituent, followed by ring enlargement through cleavage of the S-N bond.	en
heal.publisher	MARCEL DEKKER INC	en
heal.journalName	Synthetic Communications	en
dc.identifier.doi	10.1081/SCC-120026864	en
dc.identifier.isi	ISI:000187532900020	en
dc.identifier.volume	33	en
dc.identifier.issue	24	en
dc.identifier.spage	4339	en
dc.identifier.epage	4345	en