Psychophysiological evidence for altered information processing in delusional misidentification syndromes

Papageorgiou, C; Ventouras, E; Lykouras, L; Uzunoglu, N; Christodoulou, GN

dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Ventouras, E	en
dc.contributor.author	Lykouras, L	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Christodoulou, GN	en
dc.date.accessioned	2014-03-01T01:19:27Z
dc.date.available	2014-03-01T01:19:27Z
dc.date.issued	2003	en
dc.identifier.issn	0278-5846	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15506
dc.subject	Capgras syndrome	en
dc.subject	Delusional misidentification syndromes	en
dc.subject	Event-related potentials	en
dc.subject	Frégoli syndrome	en
dc.subject	P300	en
dc.subject	Working memory	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Neurosciences	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.classification	Psychiatry	en
dc.subject.other	adult	en
dc.subject.other	age	en
dc.subject.other	article	en
dc.subject.other	brain region	en
dc.subject.other	clinical article	en
dc.subject.other	cognitive defect	en
dc.subject.other	controlled study	en
dc.subject.other	delusion	en
dc.subject.other	education	en
dc.subject.other	event related potential	en
dc.subject.other	evoked auditory response	en
dc.subject.other	female	en
dc.subject.other	gray matter	en
dc.subject.other	human	en
dc.subject.other	information processing	en
dc.subject.other	male	en
dc.subject.other	patient	en
dc.subject.other	psychophysiology	en
dc.subject.other	sex	en
dc.subject.other	working memory	en
dc.subject.other	Adult	en
dc.subject.other	Analysis of Variance	en
dc.subject.other	Evoked Potentials, Auditory	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Logistic Models	en
dc.subject.other	Male	en
dc.subject.other	Mental Processes	en
dc.subject.other	Schizophrenia, Paranoid	en
dc.subject.other	Statistics, Nonparametric	en
dc.title	Psychophysiological evidence for altered information processing in delusional misidentification syndromes	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/S0278-5846(02)00353-6	en
heal.identifier.secondary	http://dx.doi.org/10.1016/S0278-5846(02)00353-6	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	Recent research provides evidence that delusional misidentification syndromes (DMS) are associated with cognitive deficits. However, the underlying mechanisms of these deficits are not known. Since the P300 component of event-related potentials (ERPs) is related to fundamental aspects of working memory (WM), the present study is focused on P300 elicited during a WM test in DMS patients, as compared to those of healthy controls. Nine patients with DMS and 11 healthy controls, matched for age, sex and educational level were tested with a computerized version of the digit span test of the Wechsler batteries. Auditory ERPs were measured during the anticipatory period of the test. DMS patients showed significant reductions in P300 amplitude at the right frontal region compared to healthy controls. P300 latency in the central midline brain region was significantly prolonged in the DMS group. Each of these measures classified correctly 90% of the two groups. Moreover, the memory performance of the patient group was significantly lower, relatively to healthy controls. These findings provide evidence supporting the suggestion that DMS is associated with psychophysiological alterations occurring at the right frontal region, which mediates automatic processes, as well as with an irregular allocation of attentional resources, involving the interhemispheric circuitry, possibly due to gray matter degeneration. Finally, present work points to a need for further research investigating the characteristics, causes, course and treatment of severe cognitive deficits associated with DMS. (C) 2002 Elsevier Science Inc. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Progress in Neuro-Psychopharmacology and Biological Psychiatry	en
dc.identifier.doi	10.1016/S0278-5846(02)00353-6	en
dc.identifier.isi	ISI:000182462600004	en
dc.identifier.volume	27	en
dc.identifier.issue	3	en
dc.identifier.spage	365	en
dc.identifier.epage	372	en