Working memory deficits in multiple sclerosis: A controlled study with auditory P600 correlates

Sfagos, C; Papageorgiou, CC; Kosma, KK; Kodopadelis, E; Uzunoglu, NK; Vassilopoulos, D; Rabavilas, AD

dc.contributor.author	Sfagos, C	en
dc.contributor.author	Papageorgiou, CC	en
dc.contributor.author	Kosma, KK	en
dc.contributor.author	Kodopadelis, E	en
dc.contributor.author	Uzunoglu, NK	en
dc.contributor.author	Vassilopoulos, D	en
dc.contributor.author	Rabavilas, AD	en
dc.date.accessioned	2014-03-01T01:19:42Z
dc.date.available	2014-03-01T01:19:42Z
dc.date.issued	2003	en
dc.identifier.issn	0022-3050	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15672
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Psychiatry	en
dc.subject.classification	Surgery	en
dc.subject.other	academic achievement	en
dc.subject.other	adult	en
dc.subject.other	age distribution	en
dc.subject.other	article	en
dc.subject.other	chronic disease	en
dc.subject.other	clinical article	en
dc.subject.other	controlled study	en
dc.subject.other	correlation analysis	en
dc.subject.other	disease course	en
dc.subject.other	disease duration	en
dc.subject.other	disease exacerbation	en
dc.subject.other	event related potential	en
dc.subject.other	female	en
dc.subject.other	frontal lobe	en
dc.subject.other	hemispheric dominance	en
dc.subject.other	human	en
dc.subject.other	intermethod comparison	en
dc.subject.other	latent period	en
dc.subject.other	male	en
dc.subject.other	measurement	en
dc.subject.other	multiple sclerosis	en
dc.subject.other	neuropsychological test	en
dc.subject.other	priority journal	en
dc.subject.other	sex ratio	en
dc.subject.other	working memory	en
dc.subject.other	Adult	en
dc.subject.other	Cognition Disorders	en
dc.subject.other	Evoked Potentials, Auditory	en
dc.subject.other	Female	en
dc.subject.other	Frontal Lobe	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Memory Disorders	en
dc.subject.other	Mental Processes	en
dc.subject.other	Middle Aged	en
dc.subject.other	Multiple Sclerosis	en
dc.subject.other	Reaction Time	en
dc.title	Working memory deficits in multiple sclerosis: A controlled study with auditory P600 correlates	en
heal.type	journalArticle	en
heal.identifier.primary	10.1136/jnnp.74.9.1231	en
heal.identifier.secondary	http://dx.doi.org/10.1136/jnnp.74.9.1231	en
heal.language	English	en
heal.publicationDate	2003	en
heal.abstract	Background: Recently, the P600 component of event related potentials, a waveform that is conceived to be generated and/or modulated by basal ganglia and cingulate area has been considered an index of the completion of any synchronised operation after target detection, having much in common with working memory operation. Moreover, dysfunction of these brain structures as well as working memory deficits have been implicated in the pathophysiology of multiple sclerosis. The aim of this study was to investigate the patterns of P600 elicited during a working memory test in multiple sclerosis patients compared with healthy controls. Methods: Twenty two definite, chronic progressive multiple sclerosis patients, with recent exacerbation of their illness, and 20 normal subjects matched for age, sex, and educational level, were studied with a computerised version of the digit span test of Wechsler batteries. Auditory P600 were measured during the anticipatory period of this test. Results: The patient group, as compared with healthy controls, showed significantly reduced latencies of P600 at left frontal areas and reduced P600 amplitudes at left temporoparietal region. Moreover, memory performance of patients was significantly more impaired when compared with healthy controls. Conclusions: These findings may indicate that multiple sclerosis is associated with abnormal features of the completion of synchronised operation after target detection, as they are reflected by P600 amplitudes and latencies. Dysfunction of this mechanism may contribute to the identification of basic cognitive processes that could account for the cognitive deficits in multiple sclerosis.	en
heal.publisher	BRITISH MED JOURNAL PUBL GROUP	en
heal.journalName	Journal of Neurology, Neurosurgery and Psychiatry	en
dc.identifier.doi	10.1136/jnnp.74.9.1231	en
dc.identifier.isi	ISI:000184881200010	en
dc.identifier.volume	74	en
dc.identifier.issue	9	en
dc.identifier.spage	1231	en
dc.identifier.epage	1235	en