A four-dimensional simulation model of tumour response to radiotherapy in vivo: Parametric validation considering radiosensitivity, genetic profile and fractionation

Dionysiou, DD; Stamatakos, GS; Uzunoglu, NK; Nikita, KS; Marioli, A

dc.contributor.author	Dionysiou, DD	en
dc.contributor.author	Stamatakos, GS	en
dc.contributor.author	Uzunoglu, NK	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Marioli, A	en
dc.date.accessioned	2014-03-01T01:19:44Z
dc.date.available	2014-03-01T01:19:44Z
dc.date.issued	2004	en
dc.identifier.issn	0022-5193	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15688
dc.subject	Cancer	en
dc.subject	Computer simulation	en
dc.subject	Modelling	en
dc.subject	Radiotherapy	en
dc.subject	Tumour	en
dc.subject.classification	Biology	en
dc.subject.classification	Mathematical & Computational Biology	en
dc.subject.other	cancer	en
dc.subject.other	four-dimensional modeling	en
dc.subject.other	theoretical study	en
dc.subject.other	tumor	en
dc.subject.other	algorithm	en
dc.subject.other	analytical parameters	en
dc.subject.other	article	en
dc.subject.other	cancer model	en
dc.subject.other	cancer radiotherapy	en
dc.subject.other	cell cycle	en
dc.subject.other	clinical examination	en
dc.subject.other	comparative study	en
dc.subject.other	decision support system	en
dc.subject.other	genetics	en
dc.subject.other	glioblastoma	en
dc.subject.other	human	en
dc.subject.other	priority journal	en
dc.subject.other	qualitative analysis	en
dc.subject.other	radiosensitivity	en
dc.subject.other	simulation	en
dc.subject.other	solid tumor	en
dc.subject.other	tumor growth	en
dc.subject.other	validation process	en
dc.subject.other	Brain Neoplasms	en
dc.subject.other	Cell Division	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Glioblastoma	en
dc.subject.other	Humans	en
dc.subject.other	Models, Biological	en
dc.subject.other	Models, Statistical	en
dc.subject.other	Neoplasms	en
dc.subject.other	Radiation Tolerance	en
dc.subject.other	Radiotherapy Planning, Computer-Assisted	en
dc.title	A four-dimensional simulation model of tumour response to radiotherapy in vivo: Parametric validation considering radiosensitivity, genetic profile and fractionation	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.jtbi.2004.03.024	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.jtbi.2004.03.024	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	The aim of this paper is to present the current state of a four-dimensional simulation model of solid tumour growth and response to radiotherapy developed by our group. The most prominent points of the algorithms describing the fundamental biological phenomena involved are outlined. A specific application of the model to a selected clinical case of glioblastoma multiforme is described and comparative studies are performed, using various exploratory values of the model parameters. Qualitative agreement with clinical observations has been achieved. Special emphasis is laid on the variability of radiosensitivity parameters throughout the cell cycle and on the influence of the genetic profile of the tumour on its radiosensitivity. The results of the simulation are three-dimensionally reconstructed. A valuable tool for getting insight into the biology of tumour growth and response to radiotherapy and at the same time an advanced patient specific decision support system is expected to emerge after the completion of the necessary extensive clinical evaluation. (C) 2004 Elsevier Ltd. All rights reserved.	en
heal.publisher	ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD	en
heal.journalName	Journal of Theoretical Biology	en
dc.identifier.doi	10.1016/j.jtbi.2004.03.024	en
dc.identifier.isi	ISI:000223521400001	en
dc.identifier.volume	230	en
dc.identifier.issue	1	en
dc.identifier.spage	1	en
dc.identifier.epage	20	en