A novel short-step synthesis of functionalized 4-hydroxy-2-quinolones using a 1-hydroxybenzotriazole methodology

Zikou, L; Athanasellis, G; Detsi, A; Zografos, A; Mitsos, C; Igglessi-Markopoulou, O

dc.contributor.author	Zikou, L	en
dc.contributor.author	Athanasellis, G	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Zografos, A	en
dc.contributor.author	Mitsos, C	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:19:46Z
dc.date.available	2014-03-01T01:19:46Z
dc.date.issued	2004	en
dc.identifier.issn	0009-2673	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15707
dc.subject.classification	Chemistry, Multidisciplinary	en
dc.subject.other	Hydroxy groups	en
dc.subject.other	Quinolone derivatives	en
dc.subject.other	Chemical activation	en
dc.subject.other	Chemical analysis	en
dc.subject.other	Derivatives	en
dc.subject.other	Reaction kinetics	en
dc.subject.other	Substitution reactions	en
dc.subject.other	Synthesis (chemical)	en
dc.subject.other	1 hydroxybenzotriazole	en
dc.subject.other	4 hydroxy 1 methyl 2 quinolone	en
dc.subject.other	4 hydroxy 1 phenyl 2 quinolone	en
dc.subject.other	anthranilic acid derivative	en
dc.subject.other	benzotriazole derivative	en
dc.subject.other	carbenoid	en
dc.subject.other	ethyl 4 hydroxy 1 methyl 2(1h) oxoquinoline 3 carboxylate	en
dc.subject.other	ethyl 4 hydroxy 2(1h) oxo 1 phenylquinoline 3 carboxylate	en
dc.subject.other	heterocyclic compound	en
dc.subject.other	methyl 4 hydroxy 1 methyl 2(1h) oxoquinoline 3 carboxylate	en
dc.subject.other	methyl 4 hydroxy 2(1h) oxo 1 phenylquinoline 3 carboxylate	en
dc.subject.other	natural product	en
dc.subject.other	quinolone derivative	en
dc.subject.other	unclassified drug	en
dc.subject.other	acylation	en
dc.subject.other	article	en
dc.subject.other	carbon nuclear magnetic resonance	en
dc.subject.other	cyclization	en
dc.subject.other	drug synthesis	en
dc.subject.other	proton nuclear magnetic resonance	en
dc.subject.other	reaction time	en
dc.title	A novel short-step synthesis of functionalized 4-hydroxy-2-quinolones using a 1-hydroxybenzotriazole methodology	en
heal.type	journalArticle	en
heal.identifier.primary	10.1246/bcsj.77.1505	en
heal.identifier.secondary	http://dx.doi.org/10.1246/bcsj.77.1505	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	A novel method for the synthesis of 3-substituted 4-hydroxy-1-methyl- and 1-phenyl-2-quinolones is presented. The compounds are produced in a one-step reaction in very good yields (51-76%). The major advantage of the methodology is the short time for the synthesis in contrast to previous methodologies requiring several steps and harsh conditions for the synthesis of quinolone derivatives.	en
heal.publisher	CHEMICAL SOC JAPAN	en
heal.journalName	Bulletin of the Chemical Society of Japan	en
dc.identifier.doi	10.1246/bcsj.77.1505	en
dc.identifier.isi	ISI:000223607000011	en
dc.identifier.volume	77	en
dc.identifier.issue	8	en
dc.identifier.spage	1505	en
dc.identifier.epage	1508	en