An unexpected simple synthesis of N-substituted 2-acetoxy-5-arylpyrroles and their hydrolysis to 3 and 4-pyrrolin-2-ones

Tsolomiti, G; Tsolomitis, A

dc.contributor.author	Tsolomiti, G	en
dc.contributor.author	Tsolomitis, A	en
dc.date.accessioned	2014-03-01T01:19:54Z
dc.date.available	2014-03-01T01:19:54Z
dc.date.issued	2004	en
dc.identifier.issn	0040-4039	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/15758
dc.subject	2-Acetoxypyrroles	en
dc.subject	3-Aroylpropionamides	en
dc.subject	3-Pyrrolin-2-ones	en
dc.subject	Acetyl chloride	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	alkali	en
dc.subject.other	chloride	en
dc.subject.other	ketone derivative	en
dc.subject.other	propionamide derivative	en
dc.subject.other	pyrrole derivative	en
dc.subject.other	article	en
dc.subject.other	drug synthesis	en
dc.subject.other	hydrolysis	en
dc.subject.other	substitution reaction	en
dc.title	An unexpected simple synthesis of N-substituted 2-acetoxy-5-arylpyrroles and their hydrolysis to 3 and 4-pyrrolin-2-ones	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.tetlet.2004.10.136	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.tetlet.2004.10.136	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	The preparation of 2-acetoxy-5-arylpyrroles and 3-pyrrolin-2-ones, from 3-aroylpropionamides and acetyl chloride, is described. The unexpected synthesis of N-substituted 2-acetoxy-5-arylpyrroles, from the reaction of 3-aroyl-propionamides with a large excess of refluxing acetyl chloride, and their alkaline hydrolysis to 3- and 4-pyrrolin-2-ones, is described. © 2004 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Tetrahedron Letters	en
dc.identifier.doi	10.1016/j.tetlet.2004.10.136	en
dc.identifier.isi	ISI:000225648700010	en
dc.identifier.volume	45	en
dc.identifier.issue	51	en
dc.identifier.spage	9353	en
dc.identifier.epage	9355	en