Long-term abstinence syndrome in heroin addicts: Indices of P300 alterations associated with a short memory task

Papageorgiou, CC; Liappas, IA; Ventouras, EM; Nikolaou, CC; Kitsonas, EN; Uzunoglu, NK; Rabavilas, AD

dc.contributor.author	Papageorgiou, CC	en
dc.contributor.author	Liappas, IA	en
dc.contributor.author	Ventouras, EM	en
dc.contributor.author	Nikolaou, CC	en
dc.contributor.author	Kitsonas, EN	en
dc.contributor.author	Uzunoglu, NK	en
dc.contributor.author	Rabavilas, AD	en
dc.date.accessioned	2014-03-01T01:20:46Z
dc.date.available	2014-03-01T01:20:46Z
dc.date.issued	2004	en
dc.identifier.issn	0278-5846	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16030
dc.subject	Addiction	en
dc.subject	Drug dependence	en
dc.subject	Event-related potentials	en
dc.subject	Heroin	en
dc.subject	Opioids	en
dc.subject	P300	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Neurosciences	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.classification	Psychiatry	en
dc.subject.other	diamorphine	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	clinical article	en
dc.subject.other	cognition	en
dc.subject.other	controlled study	en
dc.subject.other	drug dependence	en
dc.subject.other	event related potential	en
dc.subject.other	female	en
dc.subject.other	heroin dependence	en
dc.subject.other	human	en
dc.subject.other	long term care	en
dc.subject.other	male	en
dc.subject.other	memory	en
dc.subject.other	psychophysiology	en
dc.subject.other	sex difference	en
dc.subject.other	statistical significance	en
dc.subject.other	task performance	en
dc.subject.other	withdrawal syndrome	en
dc.subject.other	Acoustic Stimulation	en
dc.subject.other	Adult	en
dc.subject.other	Cues	en
dc.subject.other	Electrooculography	en
dc.subject.other	Event-Related Potentials, P300	en
dc.subject.other	Female	en
dc.subject.other	Heroin	en
dc.subject.other	Heroin Dependence	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Memory, Short-Term	en
dc.subject.other	Mental Recall	en
dc.subject.other	Narcotics	en
dc.subject.other	Neuropsychological Tests	en
dc.subject.other	Psychiatric Status Rating Scales	en
dc.subject.other	Psychomotor Performance	en
dc.subject.other	Substance Withdrawal Syndrome	en
dc.title	Long-term abstinence syndrome in heroin addicts: Indices of P300 alterations associated with a short memory task	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.pnpbp.2004.05.049	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.pnpbp.2004.05.049	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	Attentional deficits have been implicated in the pathophysiology of opioid addicts. The P300 component of event-related potentials (ERPs) is considered as a manifestation of attentional operations. The authors' goal was the comparison of P300 elicited during a short memory test between subjects with prolonged heroin abstinence and current heroin users as well as healthy controls. The P300 component was evaluated during the anticipatory period of a short memory task in 20 patients characterized by a past history of opioid dependence (6 months abstinence), in 18 current heroin users and in 20 healthy comparison subjects, matched for age, sex and educational level. Abstinent heroin addicts exhibited significant reduction of P300 amplitude at central frontal region, relative to the other two groups. The findings are discussed in connection to the aim of identifying psychophysiological indices, addressing issues in opioid use disorders, and suggest that knowledge about cognitive operations, such as those reflected by P300 component, could provide further insight into psychophysiological mechanisms underlying the long-term abstinence state of heroin addicts. (C) 2004 Elsevier Inc. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Progress in Neuro-Psychopharmacology and Biological Psychiatry	en
dc.identifier.doi	10.1016/j.pnpbp.2004.05.049	en
dc.identifier.isi	ISI:000225602200006	en
dc.identifier.volume	28	en
dc.identifier.issue	7	en
dc.identifier.spage	1109	en
dc.identifier.epage	1115	en