Phase behaviour of transkarbam 12

Zbytovska, J; Raudenkolb, S; Wartewig, S; Hubner, W; Rettig, W; Pissis, P; Hrabalek, A; Dolezal, P; Neubert, RHH

dc.contributor.author	Zbytovska, J	en
dc.contributor.author	Raudenkolb, S	en
dc.contributor.author	Wartewig, S	en
dc.contributor.author	Hubner, W	en
dc.contributor.author	Rettig, W	en
dc.contributor.author	Pissis, P	en
dc.contributor.author	Hrabalek, A	en
dc.contributor.author	Dolezal, P	en
dc.contributor.author	Neubert, RHH	en
dc.date.accessioned	2014-03-01T01:21:13Z
dc.date.available	2014-03-01T01:21:13Z
dc.date.issued	2004	en
dc.identifier.issn	0009-3084	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16143
dc.subject	DSC	en
dc.subject	FT-Raman spectroscopy	en
dc.subject	FTIR	en
dc.subject	Phase behaviour	en
dc.subject	Transkarbam	en
dc.subject	X-ray powder diffraction	en
dc.subject.classification	Biochemistry & Molecular Biology	en
dc.subject.classification	Biophysics	en
dc.subject.other	carbamic acid derivative	en
dc.subject.other	ester derivative	en
dc.subject.other	hydrocarbon	en
dc.subject.other	omega aminocaproic acid dodecyl ester	en
dc.subject.other	transkarbam 12	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	chemical analysis	en
dc.subject.other	chemical structure	en
dc.subject.other	conformation	en
dc.subject.other	differential scanning calorimetry	en
dc.subject.other	heating	en
dc.subject.other	infrared radiation	en
dc.subject.other	infrared spectroscopy	en
dc.subject.other	melting point	en
dc.subject.other	permeability	en
dc.subject.other	priority journal	en
dc.subject.other	Raman spectrometry	en
dc.subject.other	room temperature	en
dc.subject.other	structure analysis	en
dc.subject.other	synthesis	en
dc.subject.other	technique	en
dc.subject.other	temperature dependence	en
dc.subject.other	X ray powder diffraction	en
dc.subject.other	6-Aminocaproic Acid	en
dc.subject.other	Calorimetry, Differential Scanning	en
dc.subject.other	Carbamates	en
dc.subject.other	Dodecanol	en
dc.subject.other	Humans	en
dc.subject.other	Spectroscopy, Fourier Transform Infrared	en
dc.subject.other	Spectrum Analysis	en
dc.subject.other	Spectrum Analysis, Raman	en
dc.subject.other	Temperature	en
dc.subject.other	X-Ray Diffraction	en
dc.title	Phase behaviour of transkarbam 12	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.chemphyslip.2003.12.004	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.chemphyslip.2003.12.004	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	Transkarbam 12 (T12), the carbamic acid salt of omega-aminocaproic acid dodecyl ester, is a recently synthesized substance, whose high permeation enhancing activity through the human skin was found for certain drugs. In this work, the thermotropic phase behaviour of T12 has been studied by means of various techniques, namely, DSC, FTIR and FT-Raman spectroscopy, X-ray powder diffraction, and DRS. The temperature development of the X-ray reflections as well as of the conformationally sensitive Raman bands and the IR bands have been observed. At room temperature, the hydrocarbon chains of T12 exhibit a highly ordered structure, arranged in an orthorhombic perpendicular subcell. On heating, two transitions occur at 54 and at 66 degreesC. The first transition is related to the disruption of the carbamate structure and changes in the polar head group. The other transition represents the melting of hydrocarbon chains and the subsequent release of carbon dioxide. The time required for the rebinding of carbon dioxide and the reformation of the carbamate structure is dependent upon numerous factors and it was not possible to precisely determine the length of this process. (C) 2004 Elsevier Ireland Ltd. All rights reserved.	en
heal.publisher	ELSEVIER SCI IRELAND LTD	en
heal.journalName	Chemistry and Physics of Lipids	en
dc.identifier.doi	10.1016/j.chemphyslip.2003.12.004	en
dc.identifier.isi	ISI:000220344100009	en
dc.identifier.volume	129	en
dc.identifier.issue	1	en
dc.identifier.spage	97	en
dc.identifier.epage	109	en