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Phase behaviour of transkarbam 12

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dc.contributor.author Zbytovska, J en
dc.contributor.author Raudenkolb, S en
dc.contributor.author Wartewig, S en
dc.contributor.author Hubner, W en
dc.contributor.author Rettig, W en
dc.contributor.author Pissis, P en
dc.contributor.author Hrabalek, A en
dc.contributor.author Dolezal, P en
dc.contributor.author Neubert, RHH en
dc.date.accessioned 2014-03-01T01:21:13Z
dc.date.available 2014-03-01T01:21:13Z
dc.date.issued 2004 en
dc.identifier.issn 0009-3084 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/16143
dc.subject DSC en
dc.subject FT-Raman spectroscopy en
dc.subject FTIR en
dc.subject Phase behaviour en
dc.subject Transkarbam en
dc.subject X-ray powder diffraction en
dc.subject.classification Biochemistry & Molecular Biology en
dc.subject.classification Biophysics en
dc.subject.other carbamic acid derivative en
dc.subject.other ester derivative en
dc.subject.other hydrocarbon en
dc.subject.other omega aminocaproic acid dodecyl ester en
dc.subject.other transkarbam 12 en
dc.subject.other unclassified drug en
dc.subject.other article en
dc.subject.other chemical analysis en
dc.subject.other chemical structure en
dc.subject.other conformation en
dc.subject.other differential scanning calorimetry en
dc.subject.other heating en
dc.subject.other infrared radiation en
dc.subject.other infrared spectroscopy en
dc.subject.other melting point en
dc.subject.other permeability en
dc.subject.other priority journal en
dc.subject.other Raman spectrometry en
dc.subject.other room temperature en
dc.subject.other structure analysis en
dc.subject.other synthesis en
dc.subject.other technique en
dc.subject.other temperature dependence en
dc.subject.other X ray powder diffraction en
dc.subject.other 6-Aminocaproic Acid en
dc.subject.other Calorimetry, Differential Scanning en
dc.subject.other Carbamates en
dc.subject.other Dodecanol en
dc.subject.other Humans en
dc.subject.other Spectroscopy, Fourier Transform Infrared en
dc.subject.other Spectrum Analysis en
dc.subject.other Spectrum Analysis, Raman en
dc.subject.other Temperature en
dc.subject.other X-Ray Diffraction en
dc.title Phase behaviour of transkarbam 12 en
heal.type journalArticle en
heal.identifier.primary 10.1016/j.chemphyslip.2003.12.004 en
heal.identifier.secondary http://dx.doi.org/10.1016/j.chemphyslip.2003.12.004 en
heal.language English en
heal.publicationDate 2004 en
heal.abstract Transkarbam 12 (T12), the carbamic acid salt of omega-aminocaproic acid dodecyl ester, is a recently synthesized substance, whose high permeation enhancing activity through the human skin was found for certain drugs. In this work, the thermotropic phase behaviour of T12 has been studied by means of various techniques, namely, DSC, FTIR and FT-Raman spectroscopy, X-ray powder diffraction, and DRS. The temperature development of the X-ray reflections as well as of the conformationally sensitive Raman bands and the IR bands have been observed. At room temperature, the hydrocarbon chains of T12 exhibit a highly ordered structure, arranged in an orthorhombic perpendicular subcell. On heating, two transitions occur at 54 and at 66 degreesC. The first transition is related to the disruption of the carbamate structure and changes in the polar head group. The other transition represents the melting of hydrocarbon chains and the subsequent release of carbon dioxide. The time required for the rebinding of carbon dioxide and the reformation of the carbamate structure is dependent upon numerous factors and it was not possible to precisely determine the length of this process. (C) 2004 Elsevier Ireland Ltd. All rights reserved. en
heal.publisher ELSEVIER SCI IRELAND LTD en
heal.journalName Chemistry and Physics of Lipids en
dc.identifier.doi 10.1016/j.chemphyslip.2003.12.004 en
dc.identifier.isi ISI:000220344100009 en
dc.identifier.volume 129 en
dc.identifier.issue 1 en
dc.identifier.spage 97 en
dc.identifier.epage 109 en


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