Photodynamic therapy in normal pig stomach: Protective effect of octreotide

Mallas, E; Karamanolis, G; Zissis, M; Karvouni, E; Kostopanagiotou, G; Macropoulou, M; Serafetinidis, AA; Ladas, S; Raptis, SA

dc.contributor.author	Mallas, E	en
dc.contributor.author	Karamanolis, G	en
dc.contributor.author	Zissis, M	en
dc.contributor.author	Karvouni, E	en
dc.contributor.author	Kostopanagiotou, G	en
dc.contributor.author	Macropoulou, M	en
dc.contributor.author	Serafetinidis, AA	en
dc.contributor.author	Ladas, S	en
dc.contributor.author	Raptis, SA	en
dc.date.accessioned	2014-03-01T01:21:14Z
dc.date.available	2014-03-01T01:21:14Z
dc.date.issued	2004	en
dc.identifier.issn	0013-726X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16146
dc.subject.classification	Gastroenterology & Hepatology	en
dc.subject.classification	Surgery	en
dc.subject.other	octreotide	en
dc.subject.other	oxygen	en
dc.subject.other	tetrakis(3 hydroxyphenyl)chlorin	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	controlled study	en
dc.subject.other	cytotoxicity	en
dc.subject.other	diode laser	en
dc.subject.other	disease severity	en
dc.subject.other	gastritis	en
dc.subject.other	gastroscopy	en
dc.subject.other	histopathology	en
dc.subject.other	image analysis	en
dc.subject.other	medical assessment	en
dc.subject.other	nonhuman	en
dc.subject.other	photodynamic therapy	en
dc.subject.other	priority journal	en
dc.subject.other	splanchnic blood flow	en
dc.subject.other	stomach blood flow	en
dc.subject.other	stomach disease	en
dc.subject.other	stomach function	en
dc.subject.other	stomach mucosa	en
dc.subject.other	stomach protection	en
dc.subject.other	stomach ulcer	en
dc.subject.other	swine	en
dc.subject.other	tissue necrosis	en
dc.subject.other	treatment outcome	en
dc.subject.other	vascularization	en
dc.subject.other	Animals	en
dc.subject.other	Gastric Mucosa	en
dc.subject.other	Gastrointestinal Agents	en
dc.subject.other	Lasers	en
dc.subject.other	Mesoporphyrins	en
dc.subject.other	Models, Animal	en
dc.subject.other	Necrosis	en
dc.subject.other	Octreotide	en
dc.subject.other	Photochemotherapy	en
dc.subject.other	Photosensitizing Agents	en
dc.subject.other	Protective Agents	en
dc.subject.other	Random Allocation	en
dc.subject.other	Regional Blood Flow	en
dc.subject.other	Stomach	en
dc.subject.other	Swine	en
dc.title	Photodynamic therapy in normal pig stomach: Protective effect of octreotide	en
heal.type	journalArticle	en
heal.identifier.primary	10.1055/s-2004-825857	en
heal.identifier.secondary	http://dx.doi.org/10.1055/s-2004-825857	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	Background and Study Aims: Many factors, such as oxygen and vasculature, are involved in the cytotoxic effect of photodynamic therapy (PDT). It is known that somatostatin and its analog octreotide decrease the splanchnic blood flow and have multiple inhibitory effects in different functions of the peptic system. The aim of this experimental study was to assess the effect of octreotide administration on PDT outcome in normal pig stomach. Methods: 28 healthy pigs, randomly assigned to two groups, A and B, were studied. Pigs in both groups were sensitized with 0.3 mg/kg intravenous meta-tetra (hydroxyphenyl) chlorin (m-THPC), and 48 hours later light of wavelength 650 nm was delivered from a 50-mW diode laser for 300 s (energy fluence 15 J/cm2) through a gastroscope to the gastric mucosa. Group A underwent PDT without octreotide and group B had PDT with administration of octreotide. At 72 h after light delivery, all the animals were sacrificed for macroscopic and histological evaluation of the irradiated site. Results: The macroscopic images and the histology of the stomach PDT lesions (inflammation, ulceration, necrosis) showed significantly less severity in the group of animals with octreotide injection (group B). In this group, full-thickness necrosis was observed in 28.5%, compared with over 71.4% in group A; this was statistically significant (P < 0.05). Conclusion: Octreotide may have a modulating effect on m-TPHC PDT in normal gastric tissue in pigs, probably due to alterations of hemodynamics in the stomach and to suppression of the inflammatory process. © Georg Thieme Verlag KG Stuttgart.	en
heal.publisher	GEORG THIEME VERLAG KG	en
heal.journalName	Endoscopy	en
dc.identifier.doi	10.1055/s-2004-825857	en
dc.identifier.isi	ISI:000224234400009	en
dc.identifier.volume	36	en
dc.identifier.issue	10	en
dc.identifier.spage	893	en
dc.identifier.epage	897	en