Simulating growth dynamics and radiation response of avascular tumour spheroids - Model validation in the case of an EMT6/Ro multicellular spheroid

Zacharaki, EI; Stamatakos, GS; Nikita, KS; Uzunoglu, NK

dc.contributor.author	Zacharaki, EI	en
dc.contributor.author	Stamatakos, GS	en
dc.contributor.author	Nikita, KS	en
dc.contributor.author	Uzunoglu, NK	en
dc.date.accessioned	2014-03-01T01:21:24Z
dc.date.available	2014-03-01T01:21:24Z
dc.date.issued	2004	en
dc.identifier.issn	0169-2607	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16223
dc.subject	Cancer	en
dc.subject	EMT6 spheroid	en
dc.subject	Radiation therapy	en
dc.subject	Simulation	en
dc.subject	Surviving fraction	en
dc.subject	Tumour growth	en
dc.subject.classification	Computer Science, Interdisciplinary Applications	en
dc.subject.classification	Computer Science, Theory & Methods	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Medical Informatics	en
dc.subject.other	Biological optimization	en
dc.subject.other	Growth dynamics	en
dc.subject.other	Tumor growth rates	en
dc.subject.other	Algorithms	en
dc.subject.other	Cells	en
dc.subject.other	Computer simulation	en
dc.subject.other	Convergence of numerical methods	en
dc.subject.other	Irradiation	en
dc.subject.other	Medical imaging	en
dc.subject.other	Monte Carlo methods	en
dc.subject.other	Radiotherapy	en
dc.subject.other	Tumors	en
dc.subject.other	Drug products	en
dc.subject.other	article	en
dc.subject.other	cell cycle	en
dc.subject.other	cell cycle phase	en
dc.subject.other	cell survival	en
dc.subject.other	computer model	en
dc.subject.other	computer simulation	en
dc.subject.other	Monte Carlo method	en
dc.subject.other	nutrient supply	en
dc.subject.other	oxygen diffusion	en
dc.subject.other	spheroid cell	en
dc.subject.other	tumor	en
dc.subject.other	tumor growth	en
dc.subject.other	Algorithms	en
dc.subject.other	Cell Proliferation	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Disease Progression	en
dc.subject.other	Humans	en
dc.subject.other	Models, Biological	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Neoplasms	en
dc.subject.other	Sensitivity and Specificity	en
dc.subject.other	Spheroids, Cellular	en
dc.subject.other	Tumor Cells, Cultured	en
dc.title	Simulating growth dynamics and radiation response of avascular tumour spheroids - Model validation in the case of an EMT6/Ro multicellular spheroid	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.cmpb.2004.07.003	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.cmpb.2004.07.003	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	The goal of this paper is to provide both the basic scientist and the clinician with an advanced computational tool for performing in silico experiments aiming at supporting the process of biological optimisation of radiation therapy. Improved understanding and description of malignant tumour dynamics is an additional intermediate objective. To this end an advanced three-dimensional (3D) Monte-Carlo simulation model of both the avascular development of multicellular tumour spheroids and their response to radiation therapy is presented. The model is based upon a number of fundamental biological principles such as the transition between the cell cycle phases, the diffusion of oxygen and nutrients and the cell survival probabilities following irradiation. Efficient algorithms describing tumour expansion and shrinkage are proposed and applied. The output of the biosimulation model is introduced into the (3D) visualisation package AVS-Express, which performs the visualisation of both the external surface and the internal structure of the dynamicatly evolving tumour based on volume or surface rendering techniques. Both the numerical stability and the statistical behaviour of the simulation model have been studied and evaluated for the case of EMT6/Ro spheroids. Predicted histological structure and tumour growth rates have been shown to be in agreement with published experimental data. Furthermore, the underlying structure of the tumour spheroid as well as its response to irradiation satisfactorily agrees with laboratory experience. (C) 2004 Elsevier Ireland Ltd. All rights reserved.	en
heal.publisher	ELSEVIER SCI IRELAND LTD	en
heal.journalName	Computer Methods and Programs in Biomedicine	en
dc.identifier.doi	10.1016/j.cmpb.2004.07.003	en
dc.identifier.isi	ISI:000225120700002	en
dc.identifier.volume	76	en
dc.identifier.issue	3	en
dc.identifier.spage	193	en
dc.identifier.epage	206	en