Towards functional noninvasive imaging of excitable tissues inside the human body using focused microwave radiometry

Karanasiou, IS; Uzunoglu, NK; Papageorgiou, CC

dc.contributor.author	Karanasiou, IS	en
dc.contributor.author	Uzunoglu, NK	en
dc.contributor.author	Papageorgiou, CC	en
dc.date.accessioned	2014-03-01T01:21:39Z
dc.date.available	2014-03-01T01:21:39Z
dc.date.issued	2004	en
dc.identifier.issn	0018-9480	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16296
dc.subject	Activation of primary somatosensory (SI) cortex	en
dc.subject	Ellipsoidal conductive wall cavity	en
dc.subject	Focused microwave radiometry	en
dc.subject	Imaging of conductivity variations in biological tissues	en
dc.subject.classification	Engineering, Electrical & Electronic	en
dc.subject.other	Electric potential	en
dc.subject.other	Frequencies	en
dc.subject.other	Green's function	en
dc.subject.other	Microwaves	en
dc.subject.other	Numerical analysis	en
dc.subject.other	Radiometry	en
dc.subject.other	Research	en
dc.subject.other	Temperature distribution	en
dc.subject.other	Tissue	en
dc.subject.other	Activation of primary somatosensory (SI) cortex	en
dc.subject.other	Ellipsoidal conductive wall cavity	en
dc.subject.other	Focused microwave radiometry	en
dc.subject.other	Imaging of conductivity variations in biological tissues	en
dc.subject.other	Imaging techniques	en
dc.title	Towards functional noninvasive imaging of excitable tissues inside the human body using focused microwave radiometry	en
heal.type	journalArticle	en
heal.identifier.primary	10.1109/TMTT.2004.831999	en
heal.identifier.secondary	http://dx.doi.org/10.1109/TMTT.2004.831999	en
heal.language	English	en
heal.publicationDate	2004	en
heal.abstract	Focused microwave radiometry, aiming mainly in clinical applications at measuring temperature distributions inside the human body, may provide the capability of detecting electrical conductivity variations at microwave frequencies of excitable cell clusters, such as in the case of brain tissues. A novel microwave radiometric system, including an ellipsoidal conductive wall cavity, which provides the required beamforming and focusing, is developed for the imaging of biological tissues via contactless measurements. The measurement is realized by placing the human head in the region of the first focus and collecting the radiation converged at the second by an almost Isotropic dipole antenna connected to a sensitive radiometer operating at 3.5 GHz. In order to compute the focusing properties of the ellipsoidal reflector, an accurate electromagnetic numerical analysis is developed using a semianalytical method. The experimental part of this study focuses on measurements of activation of the primary somatosensory (SI) brain area, elicited during the application of the cold pressor test, a standard experimental condition inducing pain. Analysis of the measured data from 16 healthy subjects suggests that this methodology may be able to pick up activation of the SI during the pain conditions as compared with the nonpainful control conditions. Future research is needed in order to elucidate all the interacting factors involved in the interpretation of the presented results. Finally, potential limitations to the generalization of our results and strategies to improve the system's response are discussed.	en
heal.publisher	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC	en
heal.journalName	IEEE Transactions on Microwave Theory and Techniques	en
dc.identifier.doi	10.1109/TMTT.2004.831999	en
dc.identifier.isi	ISI:000223051400006	en
dc.identifier.volume	52	en
dc.identifier.issue	8 II	en
dc.identifier.spage	1898	en
dc.identifier.epage	1908	en