Experimental and clinical study of the combined effect of arterial stiffness and heart rate on pulse pressure: Differences between central and peripheral arteries

Papaioannou, TG; Protogerou, A; Papamichael, C; Mathioulakis, D; Tsangaris, S; Karatzis, E; Toumanidis, S; Zakopoulos, N; Lekakis, J

dc.contributor.author	Papaioannou, TG	en
dc.contributor.author	Protogerou, A	en
dc.contributor.author	Papamichael, C	en
dc.contributor.author	Mathioulakis, D	en
dc.contributor.author	Tsangaris, S	en
dc.contributor.author	Karatzis, E	en
dc.contributor.author	Toumanidis, S	en
dc.contributor.author	Zakopoulos, N	en
dc.contributor.author	Lekakis, J	en
dc.date.accessioned	2014-03-01T01:22:20Z
dc.date.available	2014-03-01T01:22:20Z
dc.date.issued	2005	en
dc.identifier.issn	0305-1870	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16536
dc.subject	arterial stiffness	en
dc.subject	central aortic pressures	en
dc.subject	compliance	en
dc.subject	experimental model	en
dc.subject	heart rate	en
dc.subject	hypertension	en
dc.subject	mock circulation	en
dc.subject	pulse pressure amplification	en
dc.subject	pulse pressure	en
dc.subject	wave reflections	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.classification	Physiology	en
dc.subject.other	TRANSLUMINAL CORONARY ANGIOPLASTY	en
dc.subject.other	SPURIOUS SYSTOLIC HYPERTENSION	en
dc.subject.other	WAVE-FORM CHARACTERISTICS	en
dc.subject.other	BLOOD-PRESSURE	en
dc.subject.other	CARDIOVASCULAR MORTALITY	en
dc.subject.other	MYOCARDIAL-INFARCTION	en
dc.subject.other	DISEASE	en
dc.subject.other	RISK	en
dc.subject.other	PREDICTOR	en
dc.subject.other	PULSATILITY	en
dc.title	Experimental and clinical study of the combined effect of arterial stiffness and heart rate on pulse pressure: Differences between central and peripheral arteries	en
heal.type	journalArticle	en
heal.identifier.primary	10.1111/j.1440-1681.2005.04174.x	en
heal.identifier.secondary	http://dx.doi.org/10.1111/j.1440-1681.2005.04174.x	en
heal.language	English	en
heal.publicationDate	2005	en
heal.abstract	1. Pulse pressure (PP) constitutes an independent predictor of cardiovascular events and mortality in various populations. Heart rate (HR) and arterial stiffness, in addition to their independent predictive value for cardiovascular complications, seem to interact with regard to the modification of PP. The aim of the present study was to investigate the association of PP with HR under different levels of arterial compliance (AC), revealing their synergistic effects. 2. Seventy-one normotensive and untreated hypertensive subjects were examined. Arterial compliance was measured by the 'area' method, whereas central blood pressures and wave reflections were evaluated using the Sphygmocor((R)) system (AtCor Medical, Sydney, NSW, Australia). A hydraulic Windkessel model was also used to evaluate the independent effect of HR and AC on PP. Peripheral PP was associated only with mean pressure and AC. In contrast, central PP was further related to HR (20 b.p.m. decrease in HR resulted in central PP augmentation by 5.6 mmHg) regardless of mean pressure, stroke volume, age and gender. However, this association was statistically significant only for subjects with lower AC (< 1.1 mL/mmHg) and not for those with more compliant arteries. These findings are also in accordance with the experimental data. 3. Aortic PP is affected to a greater degree by HR changes compared with peripheral PP. This response was observed only at high levels of arterial stiffness. 4. The present study provides the first evidence regarding the combined effect of AC and HR on aortic PP, which may lead to larger clinical or epidemiological studies aiming to optimization of drug treatment and to a possible reduction of cardiovascular risk.	en
heal.publisher	BLACKWELL PUBLISHING ASIA	en
heal.journalName	CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY	en
dc.identifier.doi	10.1111/j.1440-1681.2005.04174.x	en
dc.identifier.isi	ISI:000227380300011	en
dc.identifier.volume	32	en
dc.identifier.issue	3	en
dc.identifier.spage	210	en
dc.identifier.epage	217	en