Optical properties and chromophore concentration measurements in tissue-like phantoms

Drakaki, E; Psycharakis, S; Makropoulou, M; Serafetinides, AA

dc.contributor.author	Drakaki, E	en
dc.contributor.author	Psycharakis, S	en
dc.contributor.author	Makropoulou, M	en
dc.contributor.author	Serafetinides, AA	en
dc.date.accessioned	2014-03-01T01:22:53Z
dc.date.available	2014-03-01T01:22:53Z
dc.date.issued	2005	en
dc.identifier.issn	0030-4018	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16701
dc.subject	Absorption	en
dc.subject	Fluence distribution	en
dc.subject	Light propagation	en
dc.subject	Monte Carlo technique	en
dc.subject	Scattering media	en
dc.subject.classification	Optics	en
dc.subject.other	Absorption spectroscopy	en
dc.subject.other	Biomedical engineering	en
dc.subject.other	Dosimetry	en
dc.subject.other	Emission spectroscopy	en
dc.subject.other	Fluorescence	en
dc.subject.other	Laser beams	en
dc.subject.other	Light modulation	en
dc.subject.other	Light propagation	en
dc.subject.other	Light scattering	en
dc.subject.other	Monte Carlo methods	en
dc.subject.other	Tissue	en
dc.subject.other	Fluence distributions	en
dc.subject.other	Fluorescence spectra	en
dc.subject.other	Monte carlo technique	en
dc.subject.other	Scattering media	en
dc.subject.other	Chromophores	en
dc.title	Optical properties and chromophore concentration measurements in tissue-like phantoms	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.optcom.2005.05.013	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.optcom.2005.05.013	en
heal.language	English	en
heal.publicationDate	2005	en
heal.abstract	Biomedical laser light dosimetry relies on spatial light distribution measurements in combination with the appropriate laser-tissue interaction model that may be used to determine the tissue Optical Coefficients and the fluorophore concentration from its fluorescence spectra. Therefore. modelling of light transport in tissue. for optimization of laser dosimetry, requires the development of simple theoretical models and the experimental implementation in tissue-simulating phantoms, with known optical and fluorescence properties. Low cost phantoms were used, based on agar dissolved ill water as the transparent matrix, The latter is loaded with various amounts of Intralipid and fluorophores as light scatterer and absorbers, respectively. The optical properties of these phantoms were measured at two different visible wavelengths. By comparing the fluorescence emission spectra of the turbid samples containing the saute fluorophore in different concentrations, we can calculate the concentration. In addition. the evaluation of the scattering and absorption co-efficients allow us to predict the spatial distribution of the light intensity inside and outside of the phantom. It seems that the Monte Carlo simulation is an effective and relatively simple mathematical approach for tissue optical properties evaluation. (c) 2005 Elsevier B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Optics Communications	en
dc.identifier.doi	10.1016/j.optcom.2005.05.013	en
dc.identifier.isi	ISI:000232087500005	en
dc.identifier.volume	254	en
dc.identifier.issue	1-3	en
dc.identifier.spage	40	en
dc.identifier.epage	51	en