Psychophysiological differences in schizophrenics with and without delusional misidentification syndromes: A P300 study

Papageorgiou, C; Lykouras, L; Alevizos, B; Ventouras, E; Mourtzouchou, P; Uzunoglu, N; Christodoulou, GN; Rabavilas, A

dc.contributor.author	Papageorgiou, C	en
dc.contributor.author	Lykouras, L	en
dc.contributor.author	Alevizos, B	en
dc.contributor.author	Ventouras, E	en
dc.contributor.author	Mourtzouchou, P	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Christodoulou, GN	en
dc.contributor.author	Rabavilas, A	en
dc.date.accessioned	2014-03-01T01:22:59Z
dc.date.available	2014-03-01T01:22:59Z
dc.date.issued	2005	en
dc.identifier.issn	0278-5846	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16753
dc.subject	Cognition	en
dc.subject	Delusional misidentification syndromes	en
dc.subject	Event-related potentials	en
dc.subject	P300	en
dc.subject	Schizophrenia	en
dc.subject	Working memory	en
dc.subject.classification	Clinical Neurology	en
dc.subject.classification	Neurosciences	en
dc.subject.classification	Pharmacology & Pharmacy	en
dc.subject.classification	Psychiatry	en
dc.subject.other	adult	en
dc.subject.other	article	en
dc.subject.other	brain electrophysiology	en
dc.subject.other	brain region	en
dc.subject.other	clinical article	en
dc.subject.other	comparative study	en
dc.subject.other	controlled study	en
dc.subject.other	delusional disorder	en
dc.subject.other	event related potential	en
dc.subject.other	evoked auditory response	en
dc.subject.other	female	en
dc.subject.other	frontal cortex	en
dc.subject.other	human	en
dc.subject.other	latent period	en
dc.subject.other	male	en
dc.subject.other	memory consolidation	en
dc.subject.other	neuropsychological test	en
dc.subject.other	prefrontal cortex	en
dc.subject.other	psychophysiology	en
dc.subject.other	schizophrenia	en
dc.subject.other	working memory	en
dc.subject.other	Acoustic Stimulation	en
dc.subject.other	Adult	en
dc.subject.other	Delusions	en
dc.subject.other	Electroencephalography	en
dc.subject.other	Electrooculography	en
dc.subject.other	Event-Related Potentials, P300	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Male	en
dc.subject.other	Memory, Short-Term	en
dc.subject.other	Psychiatric Status Rating Scales	en
dc.subject.other	Psychomotor Performance	en
dc.subject.other	Schizophrenia	en
dc.subject.other	Schizophrenic Psychology	en
dc.title	Psychophysiological differences in schizophrenics with and without delusional misidentification syndromes: A P300 study	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.pnpbp.2005.01.016	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.pnpbp.2005.01.016	en
heal.language	English	en
heal.publicationDate	2005	en
heal.abstract	There is a debate on whether delusional misidentification syndromes (DMSs) and schizophrenia are distinct disorders. Information-processing deficits have been found in both. Since the P300 component of event-related potentials (ERPs) reflects attention and working memory (WM) mechanisms, the P300 elicited during a WM test was studied in schizophrenic patients with DMS in comparison to schizophrenic patients without DMS and controls. Nine schizophrenic patients with DMS, 11 without DMS and 11 healthy controls were tested with a computerized version of the digit span test of the Wechsler batteries. Auditory ERPs were measured during the anticipatory period of the test. P300 amplitude in prefrontal areas was found to be significantly reduced in schizophrenics without DMS and markedly less in DMS patients compared to controls. P300 latency in the central midline brain region was significantly prolonged in DMS patients compared to the other groups. Memory performance was significantly reduced in both patient groups as compared to healthy controls. The results may indicate abnormalities in both allocation of attentional resources and automatic orienting in schizophrenic patients with DSM. In contrast, even though schizophrenic patients without DMS exhibit partial similarities with patients suffering from DMS, they show excessive reduction of P300 amplitude located at the left frontal area. Future studies might clarify these issues. (c) 2005 Elsevier Inc. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Progress in Neuro-Psychopharmacology and Biological Psychiatry	en
dc.identifier.doi	10.1016/j.pnpbp.2005.01.016	en
dc.identifier.isi	ISI:000229348800015	en
dc.identifier.volume	29	en
dc.identifier.issue	4	en
dc.identifier.spage	593	en
dc.identifier.epage	601	en