Study of the lipophilicity of selenium species

Tsopelas, FN; Ochsenkuhn-Petropoulou, MTh; Tsantili-Kakoulidou, A; Ochsenkuhn, K-M

dc.contributor.author	Tsopelas, FN	en
dc.contributor.author	Ochsenkuhn-Petropoulou, MTh	en
dc.contributor.author	Tsantili-Kakoulidou, A	en
dc.contributor.author	Ochsenkuhn, K-M	en
dc.date.accessioned	2014-03-01T01:23:09Z
dc.date.available	2014-03-01T01:23:09Z
dc.date.issued	2005	en
dc.identifier.issn	1618-2642	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16833
dc.subject	Lipophilicity	en
dc.subject	Polarography	en
dc.subject	Selenium	en
dc.subject	Selenocystamine	en
dc.subject	Selenocystine	en
dc.subject	Selenomethionine	en
dc.subject.classification	Biochemical Research Methods	en
dc.subject.classification	Chemistry, Analytical	en
dc.subject.other	Electrochemistry	en
dc.subject.other	Environmental engineering	en
dc.subject.other	Hydrophilicity	en
dc.subject.other	Inductively coupled plasma	en
dc.subject.other	Mass spectrometry	en
dc.subject.other	pH effects	en
dc.subject.other	Polarographic analysis	en
dc.subject.other	Atomic emission spectrometry (AES)	en
dc.subject.other	Environmental matrices	en
dc.subject.other	Lipophilicity	en
dc.subject.other	Marine environment	en
dc.subject.other	Selenium	en
dc.subject.other	dimethyl diselenide	en
dc.subject.other	octanol	en
dc.subject.other	selenium derivative	en
dc.subject.other	selenocystamine	en
dc.subject.other	selenocysteine	en
dc.subject.other	selenomethionine	en
dc.subject.other	unclassified drug	en
dc.subject.other	water	en
dc.subject.other	article	en
dc.subject.other	atom	en
dc.subject.other	atomic emission spectrometry	en
dc.subject.other	calculation	en
dc.subject.other	cell fate	en
dc.subject.other	computer program	en
dc.subject.other	drug accumulation	en
dc.subject.other	drug determination	en
dc.subject.other	drug distribution	en
dc.subject.other	electrochemistry	en
dc.subject.other	environmental impact	en
dc.subject.other	extracellular matrix	en
dc.subject.other	food	en
dc.subject.other	fragmentation reaction	en
dc.subject.other	lipophilicity	en
dc.subject.other	marine environment	en
dc.subject.other	partition coefficient	en
dc.subject.other	pH	en
dc.subject.other	polarography	en
dc.subject.other	prediction	en
dc.subject.other	Hydrogen-Ion Concentration	en
dc.subject.other	Lipids	en
dc.subject.other	Seawater	en
dc.subject.other	Selenium	en
dc.subject.other	Software	en
dc.title	Study of the lipophilicity of selenium species	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s00216-004-2822-8	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s00216-004-2822-8	en
heal.language	English	en
heal.publicationDate	2005	en
heal.abstract	In this work the lipophilicity of different selenium species occurring in environmental matrices and food, Se(IV), Se(VI), selenomethionine (Se-Met), selenocystamine (Se-CM), selenocystine (Se-Cyst), and dimethyl diselenide (CH3)2Se2, was investigated in the octanol-water system, using the shaking flask method and detection with inductively coupled plasma-atomic emission spectrometry (ICP-AES), in order to assess their environmental fate and tendency to bioaccumulate. Polarography was also used for the electrochemically active Se species, Se(IV), Se-Cyst, Se-CM and (CH3)2Se2, and the results were compared with those measured by ICP-AES. Furthermore, the influence of pH was studied by determining the logarithm of the distribution coefficient, log D, at three pH values, 5, 7, and 9, as was the impact of the marine environment on the lipophilicity profile of the six investigated Se species. The results were compared with those estimated approximately by use of PrologD software, based on the Ghose-Crippen log P (P: partition coefficient) calculation system, the only system which incorporates values - even though approximate - for the atom type of Se. Finally, from our experimental data an indicative value of the Se-Se fragment for log P prediction, for use in drug design, was estimated. © Springer-Verlag 2004.	en
heal.publisher	SPRINGER HEIDELBERG	en
heal.journalName	Analytical and Bioanalytical Chemistry	en
dc.identifier.doi	10.1007/s00216-004-2822-8	en
dc.identifier.isi	ISI:000226888500017	en
dc.identifier.volume	381	en
dc.identifier.issue	2	en
dc.identifier.spage	420	en
dc.identifier.epage	426	en