Wall shear stress and related hemodynamic parameters in the fetal descending aorta derived from color Doppler velocity profiles

Struijk, PC; Stewart, PA; Fernando, KL; Mathews, VJ; Loupas, T; Steegers, EAP; Wladimiroff, JW

dc.contributor.author	Struijk, PC	en
dc.contributor.author	Stewart, PA	en
dc.contributor.author	Fernando, KL	en
dc.contributor.author	Mathews, VJ	en
dc.contributor.author	Loupas, T	en
dc.contributor.author	Steegers, EAP	en
dc.contributor.author	Wladimiroff, JW	en
dc.date.accessioned	2014-03-01T01:23:19Z
dc.date.available	2014-03-01T01:23:19Z
dc.date.issued	2005	en
dc.identifier.issn	0301-5629	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16909
dc.subject	Fetus	en
dc.subject	Wall shear stress	en
dc.subject.classification	Acoustics	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	Color	en
dc.subject.other	Doppler effect	en
dc.subject.other	Hemodynamics	en
dc.subject.other	Mathematical models	en
dc.subject.other	Fetus	en
dc.subject.other	Wall shear stress	en
dc.subject.other	Shear stress	en
dc.subject.other	aorta	en
dc.subject.other	aorta flow	en
dc.subject.other	aorta wall	en
dc.subject.other	article	en
dc.subject.other	color ultrasound flowmetry	en
dc.subject.other	descending aorta	en
dc.subject.other	female	en
dc.subject.other	gestational age	en
dc.subject.other	hemodynamics	en
dc.subject.other	human	en
dc.subject.other	linear system	en
dc.subject.other	pregnancy	en
dc.subject.other	priority journal	en
dc.subject.other	shear stress	en
dc.subject.other	Aorta, Thoracic	en
dc.subject.other	Blood Pressure	en
dc.subject.other	Endothelial Cells	en
dc.subject.other	Female	en
dc.subject.other	Fetal Growth Retardation	en
dc.subject.other	Gestational Age	en
dc.subject.other	Hemorheology	en
dc.subject.other	Humans	en
dc.subject.other	Pregnancy	en
dc.subject.other	Pregnancy Trimester, Second	en
dc.subject.other	Pregnancy Trimester, Third	en
dc.subject.other	Regional Blood Flow	en
dc.subject.other	Shear Strength	en
dc.subject.other	Ultrasonography, Doppler, Color	en
dc.subject.other	Ultrasonography, Prenatal	en
dc.title	Wall shear stress and related hemodynamic parameters in the fetal descending aorta derived from color Doppler velocity profiles	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.ultrasmedbio.2005.07.006	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.ultrasmedbio.2005.07.006	en
heal.language	English	en
heal.publicationDate	2005	en
heal.abstract	This paper presents a methodology for estimating the wall shear stress in the fetal descending aorta from color Doppler velocity profiles obtained during the second half of pregnancy. The Womersley model was applied to determine the wall shear stress and related hemodynamic parameters. Our analysis indicates that the aortic diameter can be modeled as a function of the gestational age in weeks as: Diameter (mm) = 0.17.ga + 0.15 (R-2 = 0.64, p < 0.001). The aortic volume flow showed a log linear gestational age-related increase that fit the model: F (mL/min) = e(0.08.ga+3.49) (R-2 = 0.61, p < 0.001). The Womersley number increased linearly with gestational age from 3.3 to 6.2 (p < 0.001) and the pressure gradient decreased linearly from 2.68 to 1.16 mPa/mm (p = 0.003) during the second half of pregnancy; the mean wall shear stress for the study group was 2.2 Pa (SD = 0.59) and was independent of gestational age. This study suggests that the size of the fetal aorta adapts to flow demands and maintains constant mean wall shear stress. (E-mail: p.struijk@erasmusmc.nl) (C) 2005 World Federation for Ultrasound in Medicine & Biology.	en
heal.publisher	ELSEVIER SCIENCE INC	en
heal.journalName	Ultrasound in Medicine and Biology	en
dc.identifier.doi	10.1016/j.ultrasmedbio.2005.07.006	en
dc.identifier.isi	ISI:000233368800002	en
dc.identifier.volume	31	en
dc.identifier.issue	11	en
dc.identifier.spage	1441	en
dc.identifier.epage	1450	en