A computer simulation of in vivo tumour growth and response to radiotherapy: New algorithms and parametric results

Dionysiou, DD; Stamatakos, GS; Uzunoglu, NK; Nikita, KS

dc.contributor.author	Dionysiou, DD	en
dc.contributor.author	Stamatakos, GS	en
dc.contributor.author	Uzunoglu, NK	en
dc.contributor.author	Nikita, KS	en
dc.date.accessioned	2014-03-01T01:23:23Z
dc.date.available	2014-03-01T01:23:23Z
dc.date.issued	2006	en
dc.identifier.issn	0010-4825	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16938
dc.subject	Cancer	en
dc.subject	Modelling	en
dc.subject	Radiotherapy	en
dc.subject	Simulation	en
dc.subject	Tumour	en
dc.subject	Visualization	en
dc.subject.classification	Biology	en
dc.subject.classification	Computer Science, Interdisciplinary Applications	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.classification	Mathematical & Computational Biology	en
dc.subject.other	Cancer biology	en
dc.subject.other	Parametric simulations	en
dc.subject.other	Radiosensitivity	en
dc.subject.other	Algorithms	en
dc.subject.other	Computational methods	en
dc.subject.other	Computer simulation	en
dc.subject.other	Decision support systems	en
dc.subject.other	Growth kinetics	en
dc.subject.other	Radiotherapy	en
dc.subject.other	Visualization	en
dc.subject.other	Tumors	en
dc.subject.other	algorithm	en
dc.subject.other	analytic method	en
dc.subject.other	article	en
dc.subject.other	cancer research	en
dc.subject.other	computer model	en
dc.subject.other	computer simulation	en
dc.subject.other	decision support system	en
dc.subject.other	genetics	en
dc.subject.other	planning	en
dc.subject.other	priority journal	en
dc.subject.other	radiosensitivity	en
dc.subject.other	three dimensional imaging	en
dc.subject.other	tumor growth	en
dc.subject.other	Algorithms	en
dc.subject.other	Animals	en
dc.subject.other	Cell Cycle	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Humans	en
dc.subject.other	Imaging, Three-Dimensional	en
dc.subject.other	Models, Biological	en
dc.subject.other	Models, Theoretical	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Neoplasms	en
dc.subject.other	Radiation-Sensitizing Agents	en
dc.subject.other	Radiotherapy Dosage	en
dc.subject.other	Radiotherapy Planning, Computer-Assisted	en
dc.subject.other	Time Factors	en
dc.title	A computer simulation of in vivo tumour growth and response to radiotherapy: New algorithms and parametric results	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.compbiomed.2005.02.003	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.compbiomed.2005.02.003	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	The aim of this paper is to present the newest algorithms and simulation results of a computer model of in vivo tumour growth and response to radiotherapy. The new algorithms are analytically presented. A set of parametric simulations has been performed with special emphasis on the influence of the genetic profile of a tumour on its radiosensitivity. The results of the simulation procedure are three-dimensionally visualized and critically surveyed. The long-term goal of this work is twofold: the development of a computational tool for getting insight into cancer biology and the development of a patient-specific decision support system. (c) 2005 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	Computers in Biology and Medicine	en
dc.identifier.doi	10.1016/j.compbiomed.2005.02.003	en
dc.identifier.isi	ISI:000237186300002	en
dc.identifier.volume	36	en
dc.identifier.issue	5	en
dc.identifier.spage	448	en
dc.identifier.epage	464	en