A novel synthetic approach to the thiotetronic ring system, the key intermediate for thiolactomycin analogues

Kikionis, S; Prousis, KC; Detsi, A; Igglessi-Markopoulou, O

dc.contributor.author	Kikionis, S	en
dc.contributor.author	Prousis, KC	en
dc.contributor.author	Detsi, A	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:23:30Z
dc.date.available	2014-03-01T01:23:30Z
dc.date.issued	2006	en
dc.identifier.issn	1424-6376	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16978
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-33745615131&partnerID=40&md5=f5ac4616139ca6e9ca16d58b8fb96b7b	en
dc.subject	2-aminothiophenones	en
dc.subject	C-acylation	en
dc.subject	Tautomerism	en
dc.subject	Thiolactomycin	en
dc.subject	Thiotetronic acids	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	TETRAMIC ACIDS	en
dc.subject.other	MYCOBACTERIUM-TUBERCULOSIS	en
dc.subject.other	POTENTIAL ANTIMALARIAL	en
dc.subject.other	NATURAL-PRODUCT	en
dc.subject.other	TETRONIC ACIDS	en
dc.subject.other	AMINO-ACIDS	en
dc.subject.other	AGENTS	en
dc.subject.other	1-HYDROXYBENZOTRIAZOLE	en
dc.subject.other	(5R)-THIOLACTOMYCIN	en
dc.subject.other	INHIBITORS	en
dc.title	A novel synthetic approach to the thiotetronic ring system, the key intermediate for thiolactomycin analogues	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	The thiotetronic ring system is the key intermediate for the synthetic approach to thiolactomycin analogues. A novel one-pot synthesis of the thiotetronic ring system is described. The proposed methodology is based on a C-acylation/cyclization reaction between the N-hydroxysuccinimide esters of S-acetyl-thioglycolic acids and the appropriate active methylene compounds. 1H and 13C NMR spectroscopic data for the synthesized thiotetronic acids and 2-aminothiophenones are presented. ©ARKAT.	en
heal.publisher	ARKAT USA INC	en
heal.journalName	Arkivoc	en
dc.identifier.isi	ISI:000244432300003	en
dc.identifier.volume	2006	en
dc.identifier.issue	12	en
dc.identifier.spage	28	en
dc.identifier.epage	37	en