A simple synthesis of functionalized 2-amino-3-cyano-4-chromones by application of the N-hydroxybenzotriazole methodology

Athanasellis, G; Melagraki, G; Afantitis, A; Makridima, K; Igglessi-Markopoulou, O

dc.contributor.author	Athanasellis, G	en
dc.contributor.author	Melagraki, G	en
dc.contributor.author	Afantitis, A	en
dc.contributor.author	Makridima, K	en
dc.contributor.author	Igglessi-Markopoulou, O	en
dc.date.accessioned	2014-03-01T01:23:31Z
dc.date.available	2014-03-01T01:23:31Z
dc.date.issued	2006	en
dc.identifier.issn	1424-6376	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/16991
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-33244479407&partnerID=40&md5=c31b5c022034a0b9a69860adb8820703	en
dc.subject	Acylation	en
dc.subject	Chromones	en
dc.subject	Cyclization	en
dc.subject	N-hydroxybenzotriazole	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	ONE-POT SYNTHESIS	en
dc.subject.other	CHROMONES	en
dc.subject.other	FLAVONOIDS	en
dc.subject.other	REARRANGEMENT	en
dc.subject.other	DERIVATIVES	en
dc.subject.other	ACETYLENES	en
dc.subject.other	1-HYDROXYBENZOTRIAZOLE	en
dc.subject.other	IODOPHENOLS	en
dc.subject.other	COMPLEX	en
dc.subject.other	AGENTS	en
dc.title	A simple synthesis of functionalized 2-amino-3-cyano-4-chromones by application of the N-hydroxybenzotriazole methodology	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	A novel and simple method for the synthesis of functionalized 2-amino-3-cyano-4-chromones is reported. The title compounds were isolated after acylation of malononitrile with N-hydroxybenzotriazolyl acetylsalicylates, generated in situ by treating acetylsalicylic acid derivatives with N-hydroxybenzotriazole, followed by cyclization. The described one-pot methodology is characterized by short reaction times, high yields (68 to 77%), no side-products and provides chromones with a variety of substituents on the aromatic ring. The structure of the isolated compounds has been determined by means of 1H/13C NMR and FT-IR Spectroscopy. ©ARKAT.	en
heal.publisher	ARKAT USA INC	en
heal.journalName	Arkivoc	en
dc.identifier.isi	ISI:000244431900004	en
dc.identifier.volume	2006	en
dc.identifier.issue	10	en
dc.identifier.spage	28	en
dc.identifier.epage	34	en