Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice

Kyriazi, M; Yova, D; Rallis, M; Lima, A

dc.contributor.author	Kyriazi, M	en
dc.contributor.author	Yova, D	en
dc.contributor.author	Rallis, M	en
dc.contributor.author	Lima, A	en
dc.date.accessioned	2014-03-01T01:23:41Z
dc.date.available	2014-03-01T01:23:41Z
dc.date.issued	2006	en
dc.identifier.issn	0304-3835	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17089
dc.subject	Chemoprevention	en
dc.subject	Hairless mice	en
dc.subject	Pine bark extract	en
dc.subject	Skin carcinogenesis	en
dc.subject.classification	Oncology	en
dc.subject.other	7,12 dimethylbenz[a]anthracene	en
dc.subject.other	dimethylbenz[a]anthracene	en
dc.subject.other	flavonoid	en
dc.subject.other	melanin	en
dc.subject.other	phenol derivative	en
dc.subject.other	pinus maritima extract	en
dc.subject.other	plant extract	en
dc.subject.other	polyphenol	en
dc.subject.other	unclassified drug	en
dc.subject.other	antineoplastic agent	en
dc.subject.other	carcinogen	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	antineoplastic activity	en
dc.subject.other	article	en
dc.subject.other	chemoprophylaxis	en
dc.subject.other	controlled study	en
dc.subject.other	drug inhibition	en
dc.subject.other	drug mechanism	en
dc.subject.other	female	en
dc.subject.other	genotoxicity	en
dc.subject.other	male	en
dc.subject.other	melanoma	en
dc.subject.other	mouse	en
dc.subject.other	nonhuman	en
dc.subject.other	papilloma	en
dc.subject.other	pine	en
dc.subject.other	Pinus maritima	en
dc.subject.other	priority journal	en
dc.subject.other	skin carcinogenesis	en
dc.subject.other	skin carcinoma	en
dc.subject.other	ultraviolet radiation	en
dc.subject.other	animal	en
dc.subject.other	bark	en
dc.subject.other	chemically induced disorder	en
dc.subject.other	hairless mouse	en
dc.subject.other	metabolism	en
dc.subject.other	radiation injury	en
dc.subject.other	skin tumor	en
dc.subject.other	time	en
dc.subject.other	Animalia	en
dc.subject.other	Pinus pinaster	en
dc.subject.other	9,10-Dimethyl-1,2-benzanthracene	en
dc.subject.other	Animals	en
dc.subject.other	Anticarcinogenic Agents	en
dc.subject.other	Carcinogens	en
dc.subject.other	Female	en
dc.subject.other	Male	en
dc.subject.other	Melanins	en
dc.subject.other	Mice	en
dc.subject.other	Mice, Inbred HRS	en
dc.subject.other	Neoplasms, Radiation-Induced	en
dc.subject.other	Pinus	en
dc.subject.other	Plant Bark	en
dc.subject.other	Skin Neoplasms	en
dc.subject.other	Time Factors	en
dc.subject.other	Ultraviolet Rays	en
dc.title	Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.canlet.2005.06.005	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.canlet.2005.06.005	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	The bark extract of Pinus Maritima (PBE), a rich in phenolic acids, polyphenols and in particular flavonoids mixture, was examined for skin cancer preventive action that was evaluated in two different experimental animal tumor models induced by ultraviolet radiation (UVR) and combination of UVR with 7,12-dimethylbenz[a]anthracene. Significant decrease in the number of animals bearing tumors and the number of tumors per animal was observed in the PBE treated animals. In the same time significant increase in the viability of these animals was also observed. Furthermore, PBE delayed the appearance of tumors. These results provide strong evidence about the preventive anticancer activity of this extract on non-melanoma skin cancer and its protective effect not only from UVR, but also from more potent carcinogenic agents. (c) 2005 Elsevier Ireland Ltd. All rights reserved.	en
heal.publisher	ELSEVIER IRELAND LTD	en
heal.journalName	Cancer Letters	en
dc.identifier.doi	10.1016/j.canlet.2005.06.005	en
dc.identifier.isi	ISI:000238563500009	en
dc.identifier.volume	237	en
dc.identifier.issue	2	en
dc.identifier.spage	234	en
dc.identifier.epage	241	en