Comparative evaluation of linear and cyclic 99mTc-RGD peptides for targeting of integrins in tumor angiogenesis

Fani, M; Psimadas, D; Zikos, C; Xanthopoulos, S; Loudos, GK; Bouziotis, P; Varvarigou, AD

dc.contributor.author	Fani, M	en
dc.contributor.author	Psimadas, D	en
dc.contributor.author	Zikos, C	en
dc.contributor.author	Xanthopoulos, S	en
dc.contributor.author	Loudos, GK	en
dc.contributor.author	Bouziotis, P	en
dc.contributor.author	Varvarigou, AD	en
dc.date.accessioned	2014-03-01T01:23:42Z
dc.date.available	2014-03-01T01:23:42Z
dc.date.issued	2006	en
dc.identifier.issn	0250-7005	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17106
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-32144432142&partnerID=40&md5=85913b26817bc27d49dc55ec1e64afeb	en
dc.subject	Angiogenesis	en
dc.subject	Carbonyls	en
dc.subject	Integrins	en
dc.subject	RGD	en
dc.subject	Technetium	en
dc.subject.classification	Oncology	en
dc.subject.other	arginylglycylaspartic acid	en
dc.subject.other	arginylglycylaspartic acid tc 99m	en
dc.subject.other	integrin	en
dc.subject.other	technetium 99m	en
dc.subject.other	unclassified drug	en
dc.subject.other	vitronectin receptor	en
dc.subject.other	amino acid sequence	en
dc.subject.other	angiogenesis	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	cancer diagnosis	en
dc.subject.other	cancer invasion	en
dc.subject.other	controlled study	en
dc.subject.other	drug clearance	en
dc.subject.other	drug distribution	en
dc.subject.other	drug excretion	en
dc.subject.other	drug liver level	en
dc.subject.other	drug targeting	en
dc.subject.other	drug uptake	en
dc.subject.other	drug urine level	en
dc.subject.other	female	en
dc.subject.other	human	en
dc.subject.other	human cell	en
dc.subject.other	metastasis	en
dc.subject.other	mouse	en
dc.subject.other	nonhuman	en
dc.subject.other	priority journal	en
dc.subject.other	protein targeting	en
dc.subject.other	radiobiology	en
dc.subject.other	tumor growth	en
dc.subject.other	tumor vascularization	en
dc.subject.other	tumor xenograft	en
dc.subject.other	Animals	en
dc.subject.other	Breast Neoplasms	en
dc.subject.other	Cell Line, Tumor	en
dc.subject.other	Female	en
dc.subject.other	Humans	en
dc.subject.other	Integrin alphaVbeta3	en
dc.subject.other	Mice	en
dc.subject.other	Mice, Nude	en
dc.subject.other	Neovascularization, Pathologic	en
dc.subject.other	Oligopeptides	en
dc.subject.other	Peptides, Cyclic	en
dc.subject.other	Radiopharmaceuticals	en
dc.subject.other	Technetium Compounds	en
dc.subject.other	Tissue Distribution	en
dc.title	Comparative evaluation of linear and cyclic 99mTc-RGD peptides for targeting of integrins in tumor angiogenesis	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	Cell adhesion molecules, such as integrins, play a vital role in angiogenesis, a key pathway for tumor growth, invasion and metastasis. The integrin a(v)beta(3), which recognizes the RGD sequence (Arg-Gly-Asp), may provide a target for in vivo tumor imaging. A linear and a cyclic RGD peptide derivative (RGDfK-His and cRGDfK-His, respectively), labelled via the precursor [Tc-99m(H2O)(3)(CO)(3)](+), were comparatively evaluated and their radiobiological properties were assessed in normal and tumor-bearing mice. Biodistribution studies showed non-specific uptake in all organs, rapid blood clearance and elimination via the hepatobiliary and urinary systems. Tumor uptake was higher for the cyclic radiolabelled derivative, as the both biodistribution and imaging studies suggested. The cRGDfK-His, labelled via the fac-[Tc-99m(CO)(3)]-core, may prove to be a useful tool for early tumor detection.	en
heal.publisher	INT INST ANTICANCER RESEARCH	en
heal.journalName	Anticancer Research	en
dc.identifier.isi	ISI:000235103800058	en
dc.identifier.volume	26	en
dc.identifier.issue	1 A	en
dc.identifier.spage	431	en
dc.identifier.epage	434	en