Efficient synthesis of 2-aminothiazole-4-phenyl-5-acetamides via the open chain tautomers of γ-keto amides

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dc.contributor.author Tsolomiti, G en
dc.contributor.author Tsolomitis, A en
dc.date.accessioned 2014-03-01T01:24:14Z
dc.date.available 2014-03-01T01:24:14Z
dc.date.issued 2006 en
dc.identifier.issn 0039-7911 en
dc.identifier.uri http://hdl.handle.net/123456789/17197
dc.subject 2-Aminothiazole-4-phenyl-5-acetamides en
dc.subject 3-benzoyl-3-bromopropionamides en
dc.subject 3-benzoylpropion-amides en
dc.subject.classification Chemistry, Organic en
dc.subject.other amide en
dc.subject.other thiazole derivative en
dc.subject.other article en
dc.subject.other chemical reaction en
dc.subject.other drug structure en
dc.subject.other drug synthesis en
dc.subject.other reaction analysis en
dc.subject.other structure analysis en
dc.title Efficient synthesis of 2-aminothiazole-4-phenyl-5-acetamides via the open chain tautomers of γ-keto amides en
heal.type journalArticle en
heal.identifier.primary 10.1080/00397910500385001 en
heal.identifier.secondary http://dx.doi.org/10.1080/00397910500385001 en
heal.language English en
heal.publicationDate 2006 en
heal.abstract A simple and efficient method is described for the synthesis of new functionalized 2-aminothiazoles, the 2-aminothiazole-4-phenyl-5-acetamides 5, in 67-96% yields based on an application of the Hantzsch synthesis. The method involves the reaction of thiourea with 3-benzoyl-3-bromo-propionamides 4 prepared from the corresponding 3-benzoylpropionamides 3. The tautomeric structure of the γ-keto amides 3 and 6 is directly related to the present study, because 2-aminothiazoles 5 are readily obtained from the corresponding open chain γ-keto amides 3. Copyright © Taylor & Francis Group, LLC. en
heal.publisher TAYLOR & FRANCIS INC en
heal.journalName Synthetic Communications en
dc.identifier.doi 10.1080/00397910500385001 en
dc.identifier.isi ISI:000234819600014 en
dc.identifier.volume 36 en
dc.identifier.issue 4 en
dc.identifier.spage 501 en
dc.identifier.epage 507 en

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