Efficient synthesis of 2-aminothiazole-4-phenyl-5-acetamides via the open chain tautomers of γ-keto amides

Tsolomiti, G; Tsolomitis, A

dc.contributor.author	Tsolomiti, G	en
dc.contributor.author	Tsolomitis, A	en
dc.date.accessioned	2014-03-01T01:24:14Z
dc.date.available	2014-03-01T01:24:14Z
dc.date.issued	2006	en
dc.identifier.issn	0039-7911	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17197
dc.subject	2-Aminothiazole-4-phenyl-5-acetamides	en
dc.subject	3-benzoyl-3-bromopropionamides	en
dc.subject	3-benzoylpropion-amides	en
dc.subject.classification	Chemistry, Organic	en
dc.subject.other	amide	en
dc.subject.other	thiazole derivative	en
dc.subject.other	article	en
dc.subject.other	chemical reaction	en
dc.subject.other	drug structure	en
dc.subject.other	drug synthesis	en
dc.subject.other	reaction analysis	en
dc.subject.other	structure analysis	en
dc.title	Efficient synthesis of 2-aminothiazole-4-phenyl-5-acetamides via the open chain tautomers of γ-keto amides	en
heal.type	journalArticle	en
heal.identifier.primary	10.1080/00397910500385001	en
heal.identifier.secondary	http://dx.doi.org/10.1080/00397910500385001	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	A simple and efficient method is described for the synthesis of new functionalized 2-aminothiazoles, the 2-aminothiazole-4-phenyl-5-acetamides 5, in 67-96% yields based on an application of the Hantzsch synthesis. The method involves the reaction of thiourea with 3-benzoyl-3-bromo-propionamides 4 prepared from the corresponding 3-benzoylpropionamides 3. The tautomeric structure of the γ-keto amides 3 and 6 is directly related to the present study, because 2-aminothiazoles 5 are readily obtained from the corresponding open chain γ-keto amides 3. Copyright © Taylor & Francis Group, LLC.	en
heal.publisher	TAYLOR & FRANCIS INC	en
heal.journalName	Synthetic Communications	en
dc.identifier.doi	10.1080/00397910500385001	en
dc.identifier.isi	ISI:000234819600014	en
dc.identifier.volume	36	en
dc.identifier.issue	4	en
dc.identifier.spage	501	en
dc.identifier.epage	507	en