Mechanical behavior of colonic anastomosis in experimental settings as a measure of wound repair and tissue integrity

Ekmektzoglou, KA; Zografos, GC; Kourkoulis, SK; Dontas, IA; Giannopoulos, PK; Marinou, KA; Poulakou, MV; Perrea, DN

dc.contributor.author	Ekmektzoglou, KA	en
dc.contributor.author	Zografos, GC	en
dc.contributor.author	Kourkoulis, SK	en
dc.contributor.author	Dontas, IA	en
dc.contributor.author	Giannopoulos, PK	en
dc.contributor.author	Marinou, KA	en
dc.contributor.author	Poulakou, MV	en
dc.contributor.author	Perrea, DN	en
dc.date.accessioned	2014-03-01T01:24:38Z
dc.date.available	2014-03-01T01:24:38Z
dc.date.issued	2006	en
dc.identifier.issn	1007-9327	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17361
dc.relation.uri	http://www.scopus.com/inward/record.url?eid=2-s2.0-33750132951&partnerID=40&md5=195e676e3f4ffc5f4510b1259a475399	en
dc.subject	Anastomosis	en
dc.subject	Colon	en
dc.subject	Failure load	en
dc.subject	Mechanical behavior	en
dc.subject	Wound healing	en
dc.subject.classification	Gastroenterology & Hepatology	en
dc.subject.other	accuracy	en
dc.subject.other	anastomosis dehiscence	en
dc.subject.other	anastomosis leakage	en
dc.subject.other	animal experiment	en
dc.subject.other	animal model	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	biomechanics	en
dc.subject.other	colon anastomosis	en
dc.subject.other	controlled study	en
dc.subject.other	correlation function	en
dc.subject.other	male	en
dc.subject.other	nonhuman	en
dc.subject.other	postoperative period	en
dc.subject.other	quantitative analysis	en
dc.subject.other	rat	en
dc.subject.other	rat strain	en
dc.subject.other	tensile strength	en
dc.subject.other	wound healing	en
dc.subject.other	Anastomosis, Surgical	en
dc.subject.other	Animals	en
dc.subject.other	Colon	en
dc.subject.other	Male	en
dc.subject.other	Models, Animal	en
dc.subject.other	Models, Theoretical	en
dc.subject.other	Rats	en
dc.subject.other	Rats, Wistar	en
dc.subject.other	Surgical Wound Dehiscence	en
dc.subject.other	Tensile Strength	en
dc.subject.other	Wound Healing	en
dc.title	Mechanical behavior of colonic anastomosis in experimental settings as a measure of wound repair and tissue integrity	en
heal.type	journalArticle	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	AIM: To determine the mechanical properties of anastomotic colonic tissue in experimental settings and therefore give a measure of wound healing. METHODS: Thirty-six male Wistar rats were used as experimental models of anastomotic tissue integrity. On the 5(th) post-operative day, the tensile strength was measured by application of an axial force, providing a quantitative measure of anastomotic dehiscence and leakage. RESULTS: Diagrams of the load as a function of the time [P = P (t)] and of the displacement also as a function of time [Delta s = Delta s (t)] were recorded for each test, permitting the design of the load versus the displacement diagram and thus providing significant data about the critical values of anastomotic failure. Quantitative data were obtained concerning the anastomotic strength of both control specimens (healthy rats), as well as specimens from non-healthy rats for comparison. CONCLUSION: This experimental model provides an excellent method of measuring anastomotic strength. Despite the relative small number of specimens used, this method provides an accurate way of measuring wound repair. More experimental measurements need to be performed to correlate emerging tensile strength values to anastomotic failure. (C) 2006 The WJG Press. All rights reserved.	en
heal.publisher	W J G PRESS	en
heal.journalName	World Journal of Gastroenterology	en
dc.identifier.isi	ISI:000241216000012	en
dc.identifier.volume	12	en
dc.identifier.issue	35	en
dc.identifier.spage	5668	en
dc.identifier.epage	5673	en