Solubility of antibiotics in different solvents. 1. Hydrochloride forms of tetracycline, moxifloxacin, and ciprofloxacin

Varanda, F; Pratas De Melo, MJ; Caco, AI; Dohrn, R; Makrydaki, FA; Voutsas, E; Tassios, D; Marrucho, IM

dc.contributor.author	Varanda, F	en
dc.contributor.author	Pratas De Melo, MJ	en
dc.contributor.author	Caco, AI	en
dc.contributor.author	Dohrn, R	en
dc.contributor.author	Makrydaki, FA	en
dc.contributor.author	Voutsas, E	en
dc.contributor.author	Tassios, D	en
dc.contributor.author	Marrucho, IM	en
dc.date.accessioned	2014-03-01T01:25:10Z
dc.date.available	2014-03-01T01:25:10Z
dc.date.issued	2006	en
dc.identifier.issn	0888-5885	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17575
dc.subject.classification	Engineering, Chemical	en
dc.subject.other	Computer simulation	en
dc.subject.other	Mathematical models	en
dc.subject.other	Phase equilibria	en
dc.subject.other	Solubility	en
dc.subject.other	Solvents	en
dc.subject.other	Temperature distribution	en
dc.subject.other	Thermal effects	en
dc.subject.other	Ciprofloxacin	en
dc.subject.other	Moxifloxacin	en
dc.subject.other	Tetracycline	en
dc.subject.other	Antibiotics	en
dc.subject.other	Antibiotics	en
dc.subject.other	Computer simulation	en
dc.subject.other	Mathematical models	en
dc.subject.other	Phase equilibria	en
dc.subject.other	Solubility	en
dc.subject.other	Solvents	en
dc.subject.other	Temperature distribution	en
dc.subject.other	Thermal effects	en
dc.title	Solubility of antibiotics in different solvents. 1. Hydrochloride forms of tetracycline, moxifloxacin, and ciprofloxacin	en
heal.type	journalArticle	en
heal.identifier.primary	10.1021/ie060055v	en
heal.identifier.secondary	http://dx.doi.org/10.1021/ie060055v	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	The solubilities of tetracycline hydrochloride, moxifloxacin hydrochloride, and ciprofloxacin hydrochloride were measured in several solvents, such as water, ethanol, 2-propanol, and acetone, in the temperature range of 293.15-323.15 K for ciprofloxacin.HCl and moxifloxacin.HCl and 288.15-310.15 K for tetracycline. All the antibiotics have the same solubility order; that is, they are more soluble in water than in ethanol, and more soluble in ethanol than in 2-propanol and acetone. The solubility in water is ∼3 orders of magnitude higher than that in acetone. The modeling of the experimental solid-liquid equilibria (SLE) data, using the NRTL and UNIQUAC models, proves that these models can correlate the solubility of studied antibiotics satisfactorily in the temperature range for which experimental data are available, with the UNIQUAC model generally being slightly superior to the NRTL model, when only two adjustable parameters are used for each binary system. © 2006 American Chemical Society.	en
heal.publisher	AMER CHEMICAL SOC	en
heal.journalName	Industrial and Engineering Chemistry Research	en
dc.identifier.doi	10.1021/ie060055v	en
dc.identifier.isi	ISI:000239932100031	en
dc.identifier.volume	45	en
dc.identifier.issue	18	en
dc.identifier.spage	6368	en
dc.identifier.epage	6374	en