The role of polymer/drug interactions on the sustained release from poly(dl-lactic acid) tablets

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dc.contributor.author Proikakis, CS en
dc.contributor.author Tarantili, PA en
dc.contributor.author Andreopoulos, AG en
dc.date.accessioned 2014-03-01T01:25:16Z
dc.date.available 2014-03-01T01:25:16Z
dc.date.issued 2006 en
dc.identifier.issn 0014-3057 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/17629
dc.subject Biodegradable polymers en
dc.subject Erosion en
dc.subject Poly(lactic acid) en
dc.subject Sustained drug release en
dc.subject Swelling en
dc.subject.classification Polymer Science en
dc.subject.other Diffusers (fluid) en
dc.subject.other Drug dosage en
dc.subject.other Drug products en
dc.subject.other Erosion en
dc.subject.other Molecular weight en
dc.subject.other Organic acids en
dc.subject.other Solubility en
dc.subject.other Solutions en
dc.subject.other Swelling en
dc.subject.other Biodegradable polymers en
dc.subject.other Poly(lactic acid) en
dc.subject.other Sustained drug release en
dc.subject.other Polymers en
dc.title The role of polymer/drug interactions on the sustained release from poly(dl-lactic acid) tablets en
heal.type journalArticle en
heal.identifier.primary 10.1016/j.eurpolymj.2006.08.023 en
heal.identifier.secondary http://dx.doi.org/10.1016/j.eurpolymj.2006.08.023 en
heal.language English en
heal.publicationDate 2006 en
heal.abstract The release profiles of model drugs (propranolol HCl, diclofenac sodium, salicylic acid and sulfasalazine) from low molecular weight poly(D,L-lactic acid) [D,L-PLA] tablets immersed in buffer solutions were investigated in an attempt to explore the mechanism of the related phenomena. It was confirmed that drug release is controlled by diffusion through the polymer matrix and by the erosion of the polymer. The pH of the surrounding medium influences the drug solubility as well as swelling and degradation rate of the polymer and therefore the overall drug release process. Physicochemical interaction between D,L-PLA and drug is an additional factor which influences the degree of matrix swelling and therefore its porosity and diffusion release process. Propranolol HCl shows extended delivery time at both examined pH values (5.4 and 7.4) and especially at pH 7.4 where release was accomplished in 190 days, most probably due to its decreased solubility at higher pH values. The acidic drugs gave shorter delivery times especially at pH 7.4. A slower drug release rate and more extended delivery time at pH 7.4 in comparison with that at pH 5.4 was recorded for tablets loaded with diclofenac sodium and salicylic acid. The opposite effect was observed with samples loaded with propranolol HCl. (c) 2006 Elsevier Ltd. All rights reserved. en
heal.journalName European Polymer Journal en
dc.identifier.doi 10.1016/j.eurpolymj.2006.08.023 en
dc.identifier.isi ISI:000243035200013 en
dc.identifier.volume 42 en
dc.identifier.issue 12 en
dc.identifier.spage 3269 en
dc.identifier.epage 3276 en

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