The role of polymer/drug interactions on the sustained release from poly(dl-lactic acid) tablets

Proikakis, CS; Tarantili, PA; Andreopoulos, AG

dc.contributor.author	Proikakis, CS	en
dc.contributor.author	Tarantili, PA	en
dc.contributor.author	Andreopoulos, AG	en
dc.date.accessioned	2014-03-01T01:25:16Z
dc.date.available	2014-03-01T01:25:16Z
dc.date.issued	2006	en
dc.identifier.issn	0014-3057	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17629
dc.subject	Biodegradable polymers	en
dc.subject	Erosion	en
dc.subject	Poly(lactic acid)	en
dc.subject	Sustained drug release	en
dc.subject	Swelling	en
dc.subject.classification	Polymer Science	en
dc.subject.other	Diffusers (fluid)	en
dc.subject.other	Drug dosage	en
dc.subject.other	Drug products	en
dc.subject.other	Erosion	en
dc.subject.other	Molecular weight	en
dc.subject.other	Organic acids	en
dc.subject.other	Solubility	en
dc.subject.other	Solutions	en
dc.subject.other	Swelling	en
dc.subject.other	Biodegradable polymers	en
dc.subject.other	Poly(lactic acid)	en
dc.subject.other	Sustained drug release	en
dc.subject.other	Polymers	en
dc.title	The role of polymer/drug interactions on the sustained release from poly(dl-lactic acid) tablets	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.eurpolymj.2006.08.023	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.eurpolymj.2006.08.023	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	The release profiles of model drugs (propranolol HCl, diclofenac sodium, salicylic acid and sulfasalazine) from low molecular weight poly(D,L-lactic acid) [D,L-PLA] tablets immersed in buffer solutions were investigated in an attempt to explore the mechanism of the related phenomena. It was confirmed that drug release is controlled by diffusion through the polymer matrix and by the erosion of the polymer. The pH of the surrounding medium influences the drug solubility as well as swelling and degradation rate of the polymer and therefore the overall drug release process. Physicochemical interaction between D,L-PLA and drug is an additional factor which influences the degree of matrix swelling and therefore its porosity and diffusion release process. Propranolol HCl shows extended delivery time at both examined pH values (5.4 and 7.4) and especially at pH 7.4 where release was accomplished in 190 days, most probably due to its decreased solubility at higher pH values. The acidic drugs gave shorter delivery times especially at pH 7.4. A slower drug release rate and more extended delivery time at pH 7.4 in comparison with that at pH 5.4 was recorded for tablets loaded with diclofenac sodium and salicylic acid. The opposite effect was observed with samples loaded with propranolol HCl. (c) 2006 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	European Polymer Journal	en
dc.identifier.doi	10.1016/j.eurpolymj.2006.08.023	en
dc.identifier.isi	ISI:000243035200013	en
dc.identifier.volume	42	en
dc.identifier.issue	12	en
dc.identifier.spage	3269	en
dc.identifier.epage	3276	en