Transmission of calibration errors (input) by generalized transfer functions to the aortic pressures (output) at different hemodynamic states

Papaioannou, TG; Lekakis, JP; Karatzis, EN; Papamichael, CM; Stamatelopoulos, KS; Protogerou, AD; Mavrikakis, M; Stefanadis, C

dc.contributor.author	Papaioannou, TG	en
dc.contributor.author	Lekakis, JP	en
dc.contributor.author	Karatzis, EN	en
dc.contributor.author	Papamichael, CM	en
dc.contributor.author	Stamatelopoulos, KS	en
dc.contributor.author	Protogerou, AD	en
dc.contributor.author	Mavrikakis, M	en
dc.contributor.author	Stefanadis, C	en
dc.date.accessioned	2014-03-01T01:25:26Z
dc.date.available	2014-03-01T01:25:26Z
dc.date.issued	2006	en
dc.identifier.issn	0167-5273	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17660
dc.subject	generalized transfer functions	en
dc.subject	applanation tonometry	en
dc.subject	wave reflections	en
dc.subject	arterial stiffness	en
dc.subject	aortic pressures	en
dc.subject.classification	Cardiac & Cardiovascular Systems	en
dc.subject.other	WAVE-FORM CHARACTERISTICS	en
dc.subject.other	ARTERIAL TRANSFER-FUNCTIONS	en
dc.subject.other	BLOOD-PRESSURE	en
dc.subject.other	PULSE PRESSURE	en
dc.subject.other	CLINICAL-PRACTICE	en
dc.subject.other	EUROPEAN-SOCIETY	en
dc.subject.other	STIFFNESS	en
dc.subject.other	DERIVATION	en
dc.subject.other	DISEASE	en
dc.subject.other	HYPERTENSION	en
dc.title	Transmission of calibration errors (input) by generalized transfer functions to the aortic pressures (output) at different hemodynamic states	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.ijcard.2005.07.014	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.ijcard.2005.07.014	en
heal.language	English	en
heal.publicationDate	2006	en
heal.abstract	Background: Aortic pressure waveforms are calculated non-invasively by applying generalized transfer functions (GTF) to tonometric radial pressure waveforms. Input errors mainly during acquisition and calibration of tonometric pressures are '' transferred '' to aortic pressure calculation. The present study aimed to quantify the proportion of specific input errors which is '' transferred '' by the GTFs in a wide range of hemodynamic conditions and for different error combinations in brachial systolic (SBP) and diastolic (DBP) blood pressure measurements. Methods: Aortic pulse wave analysis was performed in 103 subjects (52 normotensive and 51 untreated hypertensive) by the SphygmoCor (R) System. Each pressure waveform was initially calibrated by sphygmomanometrical brachial pressures. Isolated, parallel and reverse errors in brachial SBP/DBP from -10 to +10 mmHg were simulated, by recalibration of the recorded radial pressure waveforms, inducing specific '' errors '' of GTF-input values. For every recalculated aortic SBP and DBP, the difference from the initial estimated value was considered to represent the '' transferred error '' to the aortic pressure estimation. Results: Parallel errors by 5 mmHg in both SBP and DBP resulted to an identical change in GTF-derived aortic pressures, as expected. When an overestimation in SBP by 5 mmHg and an underestimation in DBP by -5 mmHg occurred (reverse errors), almost 56% of this error (-2.8 mmHg) was transferred. An isolated error in brachial SBP by 5 mmHg was transmitted by 76% (-3.8 mmHg) to GTF-derived aortic SBP. In subjects with mean blood pressure > 117 mmHg or with heart rates < 74 bpm, a greater percent of the calibration error was transferred to GTF-derived blood pressures. Conclusions: Input errors in brachial pressure values result in a quantifiable effect on transfer function output (aortic pressures). The percent of the '' error transfer '' by the GTFs depends on heart rate and BP levels, which should be taken into account when applying GTFs at populations with different hemodynamic conditions. (c) 2005 Elsevier Ireland Ltd. All rights reserved.	en
heal.publisher	ELSEVIER IRELAND LTD	en
heal.journalName	INTERNATIONAL JOURNAL OF CARDIOLOGY	en
dc.identifier.doi	10.1016/j.ijcard.2005.07.014	en
dc.identifier.isi	ISI:000238298400008	en
dc.identifier.volume	110	en
dc.identifier.issue	1	en
dc.identifier.spage	46	en
dc.identifier.epage	52	en