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A simple mechanistic model of deposition of water-soluble aerosol particles in the mouth and throat

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dc.contributor.author Mitsakou, C en
dc.contributor.author Mitrakos, D en
dc.contributor.author Neofytou, P en
dc.contributor.author Housiadas, C en
dc.date.accessioned 2014-03-01T01:25:49Z
dc.date.available 2014-03-01T01:25:49Z
dc.date.issued 2007 en
dc.identifier.issn 0894-2684 en
dc.identifier.uri https://dspace.lib.ntua.gr/xmlui/handle/123456789/17760
dc.subject Aerosol dynamics en
dc.subject Hygroscopic particles en
dc.subject Mechanistic model en
dc.subject Oral inhalation en
dc.subject.classification Respiratory System en
dc.subject.other aerosol en
dc.subject.other airflow en
dc.subject.other article en
dc.subject.other calculation en
dc.subject.other computational fluid dynamics en
dc.subject.other drug delivery system en
dc.subject.other drug solubility en
dc.subject.other dynamics en
dc.subject.other flow rate en
dc.subject.other geometry en
dc.subject.other inhalation en
dc.subject.other larynx en
dc.subject.other model en
dc.subject.other mouth en
dc.subject.other oropharynx en
dc.subject.other particle size en
dc.subject.other prediction en
dc.subject.other solubility en
dc.subject.other throat en
dc.subject.other wettability en
dc.subject.other Aerosols en
dc.subject.other Humans en
dc.subject.other Models, Theoretical en
dc.subject.other Mouth en
dc.subject.other Particle Size en
dc.subject.other Pharynx en
dc.subject.other Wettability en
dc.title A simple mechanistic model of deposition of water-soluble aerosol particles in the mouth and throat en
heal.type journalArticle en
heal.identifier.primary 10.1089/jam.2007.0625 en
heal.identifier.secondary http://dx.doi.org/10.1089/jam.2007.0625 en
heal.language English en
heal.publicationDate 2007 en
heal.abstract Aerosol drugs are usually delivered to the lung by inhalation via the oral route, since aerosol deposition is much lower in the oral than in nasal airways. In the present study a practical, non-CFD-based, mechanistic model is developed, which permits an efficient calculation of deposition along the oral route with simple computational means. A simplified geometrical description of the mouth and throat region is used, based on a sequence of conducting ducts. The numerical model takes into account aerosol dynamics, which enables to express the impact on aerosol transport and deposition of the hygroscopic growth of water-soluble particles. Simulations are made for coarse particles in the range 1-17 μm, and the model predictions are found in good agreement with the available experimental data. The model predicts inertial impaction to be the dominant mechanism, and correctly reproduces the increase in the deposition with an increasing flow rate and particle diameter. Higher deposition is calculated in the oropharyngeal region than the laryngeal region, due to the significant flow direction change and constriction at the end of the oral cavity. According to the model, highly soluble particles may deposit up to 50% more than inert aerosols in the mouth-throat region. The proposed model will be useful for quick, practical calculations of deposition with a full account of aerosol dynamical processes. © 2007 Mary Ann Liebert, Inc. en
heal.publisher MARY ANN LIEBERT INC en
heal.journalName Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung en
dc.identifier.doi 10.1089/jam.2007.0625 en
dc.identifier.isi ISI:000251992400012 en
dc.identifier.volume 20 en
dc.identifier.issue 4 en
dc.identifier.spage 519 en
dc.identifier.epage 529 en


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