A simple mechanistic model of deposition of water-soluble aerosol particles in the mouth and throat

Mitsakou, C; Mitrakos, D; Neofytou, P; Housiadas, C

dc.contributor.author	Mitsakou, C	en
dc.contributor.author	Mitrakos, D	en
dc.contributor.author	Neofytou, P	en
dc.contributor.author	Housiadas, C	en
dc.date.accessioned	2014-03-01T01:25:49Z
dc.date.available	2014-03-01T01:25:49Z
dc.date.issued	2007	en
dc.identifier.issn	0894-2684	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17760
dc.subject	Aerosol dynamics	en
dc.subject	Hygroscopic particles	en
dc.subject	Mechanistic model	en
dc.subject	Oral inhalation	en
dc.subject.classification	Respiratory System	en
dc.subject.other	aerosol	en
dc.subject.other	airflow	en
dc.subject.other	article	en
dc.subject.other	calculation	en
dc.subject.other	computational fluid dynamics	en
dc.subject.other	drug delivery system	en
dc.subject.other	drug solubility	en
dc.subject.other	dynamics	en
dc.subject.other	flow rate	en
dc.subject.other	geometry	en
dc.subject.other	inhalation	en
dc.subject.other	larynx	en
dc.subject.other	model	en
dc.subject.other	mouth	en
dc.subject.other	oropharynx	en
dc.subject.other	particle size	en
dc.subject.other	prediction	en
dc.subject.other	solubility	en
dc.subject.other	throat	en
dc.subject.other	wettability	en
dc.subject.other	Aerosols	en
dc.subject.other	Humans	en
dc.subject.other	Models, Theoretical	en
dc.subject.other	Mouth	en
dc.subject.other	Particle Size	en
dc.subject.other	Pharynx	en
dc.subject.other	Wettability	en
dc.title	A simple mechanistic model of deposition of water-soluble aerosol particles in the mouth and throat	en
heal.type	journalArticle	en
heal.identifier.primary	10.1089/jam.2007.0625	en
heal.identifier.secondary	http://dx.doi.org/10.1089/jam.2007.0625	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Aerosol drugs are usually delivered to the lung by inhalation via the oral route, since aerosol deposition is much lower in the oral than in nasal airways. In the present study a practical, non-CFD-based, mechanistic model is developed, which permits an efficient calculation of deposition along the oral route with simple computational means. A simplified geometrical description of the mouth and throat region is used, based on a sequence of conducting ducts. The numerical model takes into account aerosol dynamics, which enables to express the impact on aerosol transport and deposition of the hygroscopic growth of water-soluble particles. Simulations are made for coarse particles in the range 1-17 μm, and the model predictions are found in good agreement with the available experimental data. The model predicts inertial impaction to be the dominant mechanism, and correctly reproduces the increase in the deposition with an increasing flow rate and particle diameter. Higher deposition is calculated in the oropharyngeal region than the laryngeal region, due to the significant flow direction change and constriction at the end of the oral cavity. According to the model, highly soluble particles may deposit up to 50% more than inert aerosols in the mouth-throat region. The proposed model will be useful for quick, practical calculations of deposition with a full account of aerosol dynamical processes. © 2007 Mary Ann Liebert, Inc.	en
heal.publisher	MARY ANN LIEBERT INC	en
heal.journalName	Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung	en
dc.identifier.doi	10.1089/jam.2007.0625	en
dc.identifier.isi	ISI:000251992400012	en
dc.identifier.volume	20	en
dc.identifier.issue	4	en
dc.identifier.spage	519	en
dc.identifier.epage	529	en