Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent

Vafiadi, C; Topakas, E; Alderwick, LJ; Besra, GS; Christakopoulos, P

dc.contributor.author	Vafiadi, C	en
dc.contributor.author	Topakas, E	en
dc.contributor.author	Alderwick, LJ	en
dc.contributor.author	Besra, GS	en
dc.contributor.author	Christakopoulos, P	en
dc.date.accessioned	2014-03-01T01:26:01Z
dc.date.available	2014-03-01T01:26:01Z
dc.date.issued	2007	en
dc.identifier.issn	0141-5492	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/17878
dc.subject	Enzymatic transesterification	en
dc.subject	Feruloyl esterase	en
dc.subject	Mycobacteria	en
dc.subject.classification	Biotechnology & Applied Microbiology	en
dc.subject.other	Antimycobacterial agents	en
dc.subject.other	Chemoenzymatic synthesis	en
dc.subject.other	Feruloyl esterases	en
dc.subject.other	Mycobacteria	en
dc.subject.other	Bacteria	en
dc.subject.other	Biosynthesis	en
dc.subject.other	Sugar substitutes	en
dc.subject.other	Enzymes	en
dc.subject.other	antiinfective agent	en
dc.subject.other	carboxylesterase	en
dc.subject.other	disaccharide	en
dc.subject.other	feruloyl arabinobiose	en
dc.subject.other	feruloyl esterase	en
dc.subject.other	unclassified drug	en
dc.subject.other	article	en
dc.subject.other	chemistry	en
dc.subject.other	drug effect	en
dc.subject.other	esterification	en
dc.subject.other	isolation and purification	en
dc.subject.other	metabolism	en
dc.subject.other	Mycobacterium bovis	en
dc.subject.other	synthesis	en
dc.subject.other	Anti-Bacterial Agents	en
dc.subject.other	Carboxylic Ester Hydrolases	en
dc.subject.other	Disaccharides	en
dc.subject.other	Esterification	en
dc.subject.other	Mycobacterium bovis	en
dc.subject.other	Corynascus heterothallicus	en
dc.subject.other	Corynebacterineae	en
dc.subject.other	Mycobacterium	en
dc.subject.other	Mycobacterium bovis	en
dc.subject.other	Mycobacterium bovis BCG	en
dc.subject.other	Sporothrix	en
dc.title	Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent	en
heal.type	journalArticle	en
heal.identifier.primary	10.1007/s10529-007-9440-4	en
heal.identifier.secondary	http://dx.doi.org/10.1007/s10529-007-9440-4	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	The feruloyl esterase (StFaeC) produced by Sporotrichum thermophile transfered the feruloyl group to d-arabinose using a mixture of n-hexane, t-butanol and water. About 45% conversion of d-arabinose to the feruloylated derivative was achieved. The compound had an MIC value against Mycobacterium bovis BCG of 25 μg/ml. © 2007 Springer Science+Business Media B.V.	en
heal.publisher	SPRINGER	en
heal.journalName	Biotechnology Letters	en
dc.identifier.doi	10.1007/s10529-007-9440-4	en
dc.identifier.isi	ISI:000249779300023	en
dc.identifier.volume	29	en
dc.identifier.issue	11	en
dc.identifier.spage	1771	en
dc.identifier.epage	1774	en