Improved weight management using genetic information to personalize a calorie controlled diet

Arkadianos, I; Valdes, AM; Marinos, E; Florou, A; Gill, RD; Grimaldi, KA

dc.contributor.author	Arkadianos, I	en
dc.contributor.author	Valdes, AM	en
dc.contributor.author	Marinos, E	en
dc.contributor.author	Florou, A	en
dc.contributor.author	Gill, RD	en
dc.contributor.author	Grimaldi, KA	en
dc.date.accessioned	2014-03-01T01:26:27Z
dc.date.available	2014-03-01T01:26:27Z
dc.date.issued	2007	en
dc.identifier.issn	1475-2891	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18086
dc.subject	Blood Glucose	en
dc.subject	Genetics	en
dc.subject	Individual Variation	en
dc.subject	Nutrient Requirement	en
dc.subject	Term Weighting	en
dc.subject	Weight Management	en
dc.subject	Weight Loss	en
dc.subject.classification	Nutrition & Dietetics	en
dc.subject.other	adult	en
dc.subject.other	analytic method	en
dc.subject.other	article	en
dc.subject.other	body mass	en
dc.subject.other	caloric restriction	en
dc.subject.other	controlled study	en
dc.subject.other	female	en
dc.subject.other	genetic screening	en
dc.subject.other	genetic variability	en
dc.subject.other	glucose blood level	en
dc.subject.other	health visitor	en
dc.subject.other	human	en
dc.subject.other	major clinical study	en
dc.subject.other	male	en
dc.subject.other	nutrigenetic test	en
dc.subject.other	sex difference	en
dc.subject.other	weight control	en
dc.subject.other	weight reduction	en
dc.title	Improved weight management using genetic information to personalize a calorie controlled diet	en
heal.type	journalArticle	en
heal.identifier.primary	10.1186/1475-2891-6-29	en
heal.identifier.secondary	http://dx.doi.org/10.1186/1475-2891-6-29	en
heal.identifier.secondary	29	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Background. Gene-environment studies demonstrate variability in nutrient requirements depending upon individual variations in genes affecting nutrient metabolism and transport. This study investigated whether the inclusion of genetic information to personalize a patient's diet (nutrigenetics) could improve long term weight management. Methods. Patients with a history of failures at weight loss were offered a nutrigenetic test screening 24 variants in 19 genes involved in metabolism. 50 patients were in the nutrigenetic group and 43 patients attending the same clinic were selected for comparison using algorithms to match the characteristics: age, sex, frequency of clinical visits and BMI at initial clinic visit. The second group of 43 patients did not receive a nutrigenetic test. BMI reduction at 100 and > 300 days and blood fasting glucose were measured. Results. After 300 days of follow-up individuals in the nutrigenetic group were more likely to have maintained some weight loss (73%) than those in the comparison group (32%), resulting in an age and gender adjusted OR of 5.74 (95% CI 1.74-22.52). Average BMI reduction in the nutrigenetic group was 1.93 kg/m2(5.6% loss) vs. an average BMI gain of 0.51 kg/m2(2.2% gain) (p < 0.023). Among patients with a starting blood fasting glucose of > 100 mg/dL, 57% (17/30) of the nutrigenetic group but only 25% (4/16) of the non-tested group had levels reduced to < 100 mg/dL after > 90 days of weight management therapy (OR for lowering glucose to < 100 mg/dL due to diet = 1.98 95%CI 1.01, 3.87, p < 0.046). Conclusion. Addition of nutrigenetically tailored diets resulted in better compliance, longer-term BMI reduction and improvements in blood glucose levels. © 2007 Arkadianos et al; licensee BioMed Central Ltd.	en
heal.publisher	BIOMED CENTRAL LTD	en
heal.journalName	Nutrition Journal	en
dc.identifier.doi	10.1186/1475-2891-6-29	en
dc.identifier.isi	ISI:000208216300029	en
dc.identifier.volume	6	en