Laser induced autofluorescence studies of animal skin used in modeling of human cutaneous tissue spectroscopic measurements

Drakaki, E; Borisova, E; Makropoulou, M; Avramov, L; Serafetinides, AA; Angelov, I

dc.contributor.author	Drakaki, E	en
dc.contributor.author	Borisova, E	en
dc.contributor.author	Makropoulou, M	en
dc.contributor.author	Avramov, L	en
dc.contributor.author	Serafetinides, AA	en
dc.contributor.author	Angelov, I	en
dc.date.accessioned	2014-03-01T01:26:33Z
dc.date.available	2014-03-01T01:26:33Z
dc.date.issued	2007	en
dc.identifier.issn	0909-752X	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18123
dc.subject	Animal model	en
dc.subject	Human skin	en
dc.subject	In vivo	en
dc.subject	Laser induced fluorescence spectroscopy	en
dc.subject	Post mortem	en
dc.subject.classification	Dermatology	en
dc.subject.other	Diagnosis	en
dc.subject.other	Fluorescence	en
dc.subject.other	Laser spectroscopy	en
dc.subject.other	Pathology	en
dc.subject.other	Skin	en
dc.subject.other	Cutaneous tissue	en
dc.subject.other	Laser-induced autofluorescence spectroscopy	en
dc.subject.other	Tissue	en
dc.subject.other	nitrogen	en
dc.subject.other	animal tissue	en
dc.subject.other	article	en
dc.subject.other	autofluorescence	en
dc.subject.other	chicken	en
dc.subject.other	controlled study	en
dc.subject.other	disease model	en
dc.subject.other	ex vivo study	en
dc.subject.other	excitation	en
dc.subject.other	human	en
dc.subject.other	human tissue	en
dc.subject.other	in vivo study	en
dc.subject.other	nonhuman	en
dc.subject.other	quantitative analysis	en
dc.subject.other	sampling	en
dc.subject.other	skin	en
dc.subject.other	skin examination	en
dc.subject.other	spectroscopy	en
dc.subject.other	swine	en
dc.subject.other	Animals	en
dc.subject.other	Chickens	en
dc.subject.other	Dermatology	en
dc.subject.other	Fluorescence	en
dc.subject.other	Humans	en
dc.subject.other	Lasers	en
dc.subject.other	Mice	en
dc.subject.other	Models, Animal	en
dc.subject.other	Skin Physiology	en
dc.subject.other	Species Specificity	en
dc.subject.other	Spectrum Analysis	en
dc.subject.other	Swine	en
dc.title	Laser induced autofluorescence studies of animal skin used in modeling of human cutaneous tissue spectroscopic measurements	en
heal.type	journalArticle	en
heal.identifier.primary	10.1111/j.1600-0846.2007.00237.x	en
heal.identifier.secondary	http://dx.doi.org/10.1111/j.1600-0846.2007.00237.x	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Background/purpose: Laser-induced autofluorescence spectroscopy provides excellent possibilities for medical diagnostics of different tissue pathologies including cancer. However, to create the whole picture of pathological changes, investigators collect spectral information from patients in vivo or they study different tumor models to obtain objective information for fluorescent properties of every kind of healthy and diseased tissue. Therefore, it is very important to find the most appropriate, and close to the human skin, animal samples from the fluorescence point of view, which will allow the extrapolation of the animal data to human spectroscopic diagnostics. Methods: In the present work, we examined the autofluorescence properties of different animal skin tissues, which are considered as the most common skin models. A nitrogen laser was used as an excitation source. Samples of healthy mouse, chicken and pig skin in vivo and/or ex vivo were studied and were compared with results obtained from investigations of healthy human skin in vivo. Results and conclusion: Specific features of the recorded spectra are discussed and the possible origin of the obtained fluorescence signals is proposed. Quantitative evaluation of data extrapolation for each skin type is also depicted. © 2007 Blackwell Munksgaard.	en
heal.publisher	BLACKWELL PUBLISHING	en
heal.journalName	Skin Research and Technology	en
dc.identifier.doi	10.1111/j.1600-0846.2007.00237.x	en
dc.identifier.isi	ISI:000249925300002	en
dc.identifier.volume	13	en
dc.identifier.issue	4	en
dc.identifier.spage	350	en
dc.identifier.epage	359	en