Melting point depression by using supercritical CO2 for a novel melt dispersion micronization process

Dohrn, R; Bertakis, E; Behrend, O; Voutsas, E; Tassios, D

dc.contributor.author	Dohrn, R	en
dc.contributor.author	Bertakis, E	en
dc.contributor.author	Behrend, O	en
dc.contributor.author	Voutsas, E	en
dc.contributor.author	Tassios, D	en
dc.date.accessioned	2014-03-01T01:26:37Z
dc.date.available	2014-03-01T01:26:37Z
dc.date.issued	2007	en
dc.identifier.issn	0167-7322	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18155
dc.subject	Depression	en
dc.subject	Melt dispersion	en
dc.subject	Melting point	en
dc.subject	Micronization	en
dc.subject	Supercritical	en
dc.subject.classification	Chemistry, Physical	en
dc.subject.classification	Physics, Atomic, Molecular & Chemical	en
dc.subject.other	Carbon dioxide	en
dc.subject.other	Mathematical models	en
dc.subject.other	Molten materials	en
dc.subject.other	Suspensions (fluids)	en
dc.subject.other	Thermodynamics	en
dc.subject.other	Melt dispersion micronization	en
dc.subject.other	Melting point	en
dc.subject.other	Thermodynamic model	en
dc.subject.other	Supercritical fluids	en
dc.title	Melting point depression by using supercritical CO2 for a novel melt dispersion micronization process	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.molliq.2006.08.026	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.molliq.2006.08.026	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	The melting point of solid substances can be depressed considerably by using supercritical fluids that are highly dissolvable in the molten substance. This fact can be used in micronization processes where thermo-labile materials are liquefied at a temperature lower than their normal melting point in order to produce fine particles. In the present study, the inciting points of four different materials under various pressures applied by CO2 were determined visually with the first melting point method: phenanthrene, beta-sitosterol, an insecticide, and a pharmaceutical active. The aqueous suspensions of all materials except phenanthrene were also studied. Thus, it was possible to determine the solid-liquid-vapor equilibrium lines of these materials on a temperature-pressure plane. Finally, a thermodynamic model for describing the phase equilibria of such binary systems was developed implementing the Peng-Robinson equation of state and two different approaches concerning the fugacity of the solid phase. (C) 2006 Elsevier B.V. All rights reserved.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Journal of Molecular Liquids	en
dc.identifier.doi	10.1016/j.molliq.2006.08.026	en
dc.identifier.isi	ISI:000245002500009	en
dc.identifier.volume	131-132	en
dc.identifier.issue	SPEC. ISS.	en
dc.identifier.spage	53	en
dc.identifier.epage	59	en