Monte-Carlo study of energy deposition by heavy charged particles in sub-cellular volumes

Emfietzoglou, D; Papamichael, G; Pathak, A; Fotopoulos, A; Nikjoo, H

dc.contributor.author	Emfietzoglou, D	en
dc.contributor.author	Papamichael, G	en
dc.contributor.author	Pathak, A	en
dc.contributor.author	Fotopoulos, A	en
dc.contributor.author	Nikjoo, H	en
dc.date.accessioned	2014-03-01T01:26:42Z
dc.date.available	2014-03-01T01:26:42Z
dc.date.issued	2007	en
dc.identifier.issn	0144-8420	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18182
dc.subject.classification	Environmental Sciences	en
dc.subject.classification	Public, Environmental & Occupational Health	en
dc.subject.classification	Nuclear Science & Technology	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	DNA	en
dc.subject.other	proton	en
dc.subject.other	radioisotope	en
dc.subject.other	water	en
dc.subject.other	heavy ion	en
dc.subject.other	alpha radiation	en
dc.subject.other	article	en
dc.subject.other	biological model	en
dc.subject.other	chromosome	en
dc.subject.other	gamma radiation	en
dc.subject.other	liquid	en
dc.subject.other	Monte Carlo method	en
dc.subject.other	physical model	en
dc.subject.other	prediction	en
dc.subject.other	proton radiation	en
dc.subject.other	radiation energy	en
dc.subject.other	vapor	en
dc.subject.other	cell function	en
dc.subject.other	computer simulation	en
dc.subject.other	genetics	en
dc.subject.other	linear energy transfer	en
dc.subject.other	methodology	en
dc.subject.other	radiation dose	en
dc.subject.other	radiation exposure	en
dc.subject.other	radiometry	en
dc.subject.other	Cell Physiology	en
dc.subject.other	Computer Simulation	en
dc.subject.other	DNA	en
dc.subject.other	Heavy Ions	en
dc.subject.other	Linear Energy Transfer	en
dc.subject.other	Models, Biological	en
dc.subject.other	Monte Carlo Method	en
dc.subject.other	Protons	en
dc.subject.other	Radiation Dosage	en
dc.subject.other	Radiometry	en
dc.title	Monte-Carlo study of energy deposition by heavy charged particles in sub-cellular volumes	en
heal.type	journalArticle	en
heal.identifier.primary	10.1093/rpd/ncm092	en
heal.identifier.secondary	http://dx.doi.org/10.1093/rpd/ncm092	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	Detailed-history Monte-Carlo code is used to study the energy deposition from proton and alpha particle tracks at the sub-cellular level. Inelastic cross sections for both the vapour and liquid phases of water have been implemented into the code in order to explore the influence of non-linear density effects associated with the condensed-phase cellular environment. Results of energy deposition and its straggling for 0.5 to 5 MeV amu-1 protons and alpha particles traversing or passing near spherical volumes of 2-200 nm in diameter relevant to DNA- and chromosome-size targets are presented. It is shown that the explicit account of δ-ray transport reduces the dose by as much as 10-60%, whereas stochastic fluctuations lead to a relative uncertainty ranging from 20% to more than 100%. Protons and alpha particles of the same velocity exhibit a similar δ-ray effect, whereas the relative uncertainty of the alphas is almost half that of protons. The effect of the phase is noticeable (10-15%) mainly through differences on the transport of δ-rays, which in liquid water have higher penetration distances. It is expected that the implementation of such results into multi-scale biophysical models of radiation effects will lead to a more realistic predictions on the efficacy of new radiotherapeutic modalities that employ either external proton beam irradiation or internal alpha-emitting radionuclides. © The Author 2007. Published by Oxford University Press. All rights reserved.	en
heal.publisher	OXFORD UNIV PRESS	en
heal.journalName	Radiation Protection Dosimetry	en
dc.identifier.doi	10.1093/rpd/ncm092	en
dc.identifier.isi	ISI:000254997400093	en
dc.identifier.volume	126	en
dc.identifier.issue	1-4	en
dc.identifier.spage	457	en
dc.identifier.epage	462	en