Numerical modeling of simulated blood flow in idealized composite arterial coronary grafts: Steady state simulations

Politis, AK; Stavropoulos, GP; Christolis, MN; Panagopoulos, FG; Vlachos, NS; Markatos, NC

dc.contributor.author	Politis, AK	en
dc.contributor.author	Stavropoulos, GP	en
dc.contributor.author	Christolis, MN	en
dc.contributor.author	Panagopoulos, FG	en
dc.contributor.author	Vlachos, NS	en
dc.contributor.author	Markatos, NC	en
dc.date.accessioned	2014-03-01T01:26:44Z
dc.date.available	2014-03-01T01:26:44Z
dc.date.issued	2007	en
dc.identifier.issn	0021-9290	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18212
dc.subject	CFD	en
dc.subject	Composite arterial coronary grafts	en
dc.subject	Coronary artery disease	en
dc.subject	Numerical modelling	en
dc.subject.classification	Biophysics	en
dc.subject.classification	Engineering, Biomedical	en
dc.subject.other	Blood vessels	en
dc.subject.other	Computational fluid dynamics	en
dc.subject.other	Diseases	en
dc.subject.other	Geometry	en
dc.subject.other	Shear stress	en
dc.subject.other	Surgery	en
dc.subject.other	Bypass grafts	en
dc.subject.other	Cardiac surgery	en
dc.subject.other	Composite arterial coronary grafts (CACG)	en
dc.subject.other	Coronary artery disease (CAD)	en
dc.subject.other	Wall shear stress (WSS)	en
dc.subject.other	Blood	en
dc.subject.other	anastomosis	en
dc.subject.other	artery wall	en
dc.subject.other	article	en
dc.subject.other	blood flow velocity	en
dc.subject.other	blood pressure	en
dc.subject.other	comparative study	en
dc.subject.other	composite material	en
dc.subject.other	computational fluid dynamics	en
dc.subject.other	computer analysis	en
dc.subject.other	coronary artery blood flow	en
dc.subject.other	coronary artery bypass graft	en
dc.subject.other	coronary artery disease	en
dc.subject.other	elasticity	en
dc.subject.other	heart muscle blood flow	en
dc.subject.other	heart surgery	en
dc.subject.other	hemodynamics	en
dc.subject.other	laminar flow	en
dc.subject.other	mathematical model	en
dc.subject.other	permeability	en
dc.subject.other	prediction	en
dc.subject.other	priority journal	en
dc.subject.other	qualitative analysis	en
dc.subject.other	quantitative analysis	en
dc.subject.other	shear stress	en
dc.subject.other	simulation	en
dc.subject.other	steady state	en
dc.subject.other	variance	en
dc.subject.other	Computer Simulation	en
dc.subject.other	Coronary Artery Bypass	en
dc.subject.other	Coronary Circulation	en
dc.subject.other	Coronary Vessels	en
dc.subject.other	Models, Anatomic	en
dc.subject.other	Radial Artery	en
dc.subject.other	Rheology	en
dc.title	Numerical modeling of simulated blood flow in idealized composite arterial coronary grafts: Steady state simulations	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.jbiomech.2006.05.008	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.jbiomech.2006.05.008	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	This paper presents a comparative study of simulated blood flow in different configurations of simplified composite arterial coronary grafts (CACGs). Even though the composite arterial grafting is increasingly used in cardiac surgery, it is still questionable whether or not the blood flow in such grafts can adequately meet the demands of the native myocardial circulation. A computational fluid dynamics (CFD) model was developed to conduct computer-based studies of simulated blood flow in four different geometric configurations of CACGs, corresponding to routinely used networks in cardiac surgery coronary grafts (T, Y, Pi and sequential). The flow was assumed three-dimensional, laminar and steady and the fluid as Newtonian, while the vessel walls were considered as inelastic and impermeable. It was concluded that local haemodynamics, practically described by velocity, pressure drop, wall shear stress (WSS) and flow rates, may be strongly influenced by the local geometry, especially at the anastomotic sites. The. computations were made at mean flow rates of 37.5, 75 and 150 ml/min. The side-branch outflow rates, computed for each bypass graft, showed noticeable differences. The results, which were found both qualitatively and quantitatively consistent with other studies, indicate that the Pi-graft exhibits significantly less uniform distribution of outflow rates than the other geometric configurations. Moreover, prominent variations in WSS and velocity distribution among the assessed CACGs were predicted, showing remarkable flow interactions among the arterial branches. The lowest shear stress regions were found on the lateral walls of bifurcations, which are predominantly susceptible to the occurrence of coronary artery disease (CAD). In contrast, the highest WSS were observed at the turn of the arterial branches. (c) 2006 Elsevier Ltd. All rights reserved.	en
heal.publisher	ELSEVIER SCI LTD	en
heal.journalName	Journal of Biomechanics	en
dc.identifier.doi	10.1016/j.jbiomech.2006.05.008	en
dc.identifier.isi	ISI:000245565400020	en
dc.identifier.volume	40	en
dc.identifier.issue	5	en
dc.identifier.spage	1125	en
dc.identifier.epage	1136	en