Performance evaluation of a dedicated camera suitable for dynamic radiopharmaceuticals evaluation in small animals

Loudos, G; Majewski, S; Wojcik, R; Weisenberger, A; Sakellios, N; Nikita, K; Uzunoglu, N; Bouziotis, P; Xanthopoulos, S; Varvarigou, A

dc.contributor.author	Loudos, G	en
dc.contributor.author	Majewski, S	en
dc.contributor.author	Wojcik, R	en
dc.contributor.author	Weisenberger, A	en
dc.contributor.author	Sakellios, N	en
dc.contributor.author	Nikita, K	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Bouziotis, P	en
dc.contributor.author	Xanthopoulos, S	en
dc.contributor.author	Varvarigou, A	en
dc.date.accessioned	2014-03-01T01:26:54Z
dc.date.available	2014-03-01T01:26:54Z
dc.date.issued	2007	en
dc.identifier.issn	0018-9499	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18271
dc.subject	Dedicated gamma camera	en
dc.subject	Position sensitive photomultiplier tubes	en
dc.subject	Radiopharmaceuticals	en
dc.subject	Small animal imaging	en
dc.subject.classification	Engineering, Electrical & Electronic	en
dc.subject.classification	Nuclear Science & Technology	en
dc.subject.other	Dedicated gamma camera	en
dc.subject.other	Position sensitive photomultiplier tubes	en
dc.subject.other	Radiodiagnostic Products	en
dc.subject.other	Small animal imaging	en
dc.subject.other	Biomolecules	en
dc.subject.other	Drug products	en
dc.subject.other	Medical imaging	en
dc.subject.other	Oncology	en
dc.subject.other	Radioisotopes	en
dc.subject.other	Cameras	en
dc.title	Performance evaluation of a dedicated camera suitable for dynamic radiopharmaceuticals evaluation in small animals	en
heal.type	journalArticle	en
heal.identifier.primary	10.1109/TNS.2007.896212	en
heal.identifier.secondary	http://dx.doi.org/10.1109/TNS.2007.896212	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	As the result of a collaboration between the Detector and Imaging Group of Thomas Jefferson National Accelerator Facility (US), the Institute of Radioisotopes and Radiodiagnostic Products (IRRP) of N.C.S.R. ""Demokritos"" and the Biomedical Simulations and Imaging Applications Laboratory (BIOSEVI) of National Technical University of Athens (Greece), a mouse sized camera optimized for Tc99m imaging was developed. The detector was built in Jefferson Lab and transferred to Greece, where it was evaluated with phantoms and small animals. The system will be used initially for planar dynamic studies in small animals, in order to assess the performance of new radiolabeled biomolecules for oncological studies. The active area of the detector is approximately 48 mm × 96 mm. It is based on two flat-panel Hamamatsu H8500 position sensitive photomultiplier tubes (PSPMT), a pixelated NaI(TI) scintillator and a high resolution lead parallel-hole colh'mator. The system was developed to optimize both sensitivity and resolution for in vivo imaging of small animals injected with technetium compounds. The results of system evaluation in planar mode with phantoms are reported. Results are presented for in vivo dynamic studies of mice injected with > 100 μCi of two conventional and novel radiopharmaceuticals, namely Tc99m-MDP and Tc99m -Bombesin. © 2007 IEEE.	en
heal.publisher	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC	en
heal.journalName	IEEE Transactions on Nuclear Science	en
dc.identifier.doi	10.1109/TNS.2007.896212	en
dc.identifier.isi	ISI:000247391200007	en
dc.identifier.volume	54	en
dc.identifier.issue	3	en
dc.identifier.spage	454	en
dc.identifier.epage	460	en