Performance evaluation of a mouse-sized camera for dynamic studies in small animals

Loudos, G; Majewski, S; Wojcik, R; Weisenberger, A; Sakellios, N; Nikita, K; Uzunoglu, N; Bouziotis, P; Varvarigou, A

dc.contributor.author	Loudos, G	en
dc.contributor.author	Majewski, S	en
dc.contributor.author	Wojcik, R	en
dc.contributor.author	Weisenberger, A	en
dc.contributor.author	Sakellios, N	en
dc.contributor.author	Nikita, K	en
dc.contributor.author	Uzunoglu, N	en
dc.contributor.author	Bouziotis, P	en
dc.contributor.author	Varvarigou, A	en
dc.date.accessioned	2014-03-01T01:26:54Z
dc.date.available	2014-03-01T01:26:54Z
dc.date.issued	2007	en
dc.identifier.issn	0168-9002	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18272
dc.subject	Dynamic studies	en
dc.subject	Mouse-sized camera	en
dc.subject	PSPMTs	en
dc.subject	Radiopharmaceuticals evaluation	en
dc.subject	Small animal imaging	en
dc.subject.classification	Instruments & Instrumentation	en
dc.subject.classification	Nuclear Science & Technology	en
dc.subject.classification	Physics, Particles & Fields	en
dc.subject.classification	Spectroscopy	en
dc.subject.other	Drug products	en
dc.subject.other	Imaging systems	en
dc.subject.other	Optical resolving power	en
dc.subject.other	Photodetectors	en
dc.subject.other	Radiotherapy	en
dc.subject.other	Dynamic studies	en
dc.subject.other	Mouse-sized camera	en
dc.subject.other	Radiopharmaceuticals evaluation	en
dc.subject.other	Small animal imaging	en
dc.subject.other	Cameras	en
dc.title	Performance evaluation of a mouse-sized camera for dynamic studies in small animals	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.nima.2006.10.026	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.nima.2006.10.026	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	A mouse sized camera has been built in terms of collaboration between the presenting institutions. The system is used for the performance of dynamic studies in small animals, in order to evaluate novel radiopharmaceuticals. The active area of the detector is approximately 48 x 96 mm allowing depiction of the entire mouse in a single view. The system is based on two flat-panel Hamamatsu H8500 position sensitive photomultiplier tubes (PSPMT), a pixellated NaI(Tl) scintillator and a copper-beryllium (CuBe) parallel-hole collimator. In this work, the evaluation results of the system are presented, using phantoms and small animals injected with conventional radiophrmaceuticals. Average resolution was similar to 1.6 mm on the collimator surface and increased to similar to 4.1 mm in 12cm distance from the detector. The average energy resolution was measured and found to be similar to 15.6% for Tc-99m. Results from imaging thin capillaries demonstrated system's high resolution and sensitivity in activity variations was shown. Initial dynamic studies have been carried out in small animals injected with Tc-99m-DTPA and Tc-99m-MDP. The results show system's ability to perform kinetic imaging in small animals. (c) 2006 Published by Elsevier B.V.	en
heal.publisher	ELSEVIER SCIENCE BV	en
heal.journalName	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment	en
dc.identifier.doi	10.1016/j.nima.2006.10.026	en
dc.identifier.isi	ISI:000244599100012	en
dc.identifier.volume	571	en
dc.identifier.issue	1-2 SPEC. ISS.	en
dc.identifier.spage	48	en
dc.identifier.epage	51	en