Substrate stretching and reorganization of stress fibers as a finite elasticity problem

Lazopoulos, KA; Pirentis, A

dc.contributor.author	Lazopoulos, KA	en
dc.contributor.author	Pirentis, A	en
dc.date.accessioned	2014-03-01T01:27:20Z
dc.date.available	2014-03-01T01:27:20Z
dc.date.issued	2007	en
dc.identifier.issn	0020-7683	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18405
dc.subject	Coexistence of phases	en
dc.subject	Extracellular stretching	en
dc.subject	Finite elasticity	en
dc.subject	Maxwell's stability convention	en
dc.subject	Reorientation	en
dc.subject	Stability	en
dc.subject	Stress-fibers	en
dc.subject.classification	Mechanics	en
dc.subject.other	Elasticity	en
dc.subject.other	Problem solving	en
dc.subject.other	Stress analysis	en
dc.subject.other	Stretching	en
dc.subject.other	Coexistence of phases	en
dc.subject.other	Extracellular stretching	en
dc.subject.other	Finite elasticity	en
dc.subject.other	Maxwell's stability convention	en
dc.subject.other	Reorientation	en
dc.subject.other	Stress-fibers	en
dc.subject.other	Substrates	en
dc.title	Substrate stretching and reorganization of stress fibers as a finite elasticity problem	en
heal.type	journalArticle	en
heal.identifier.primary	10.1016/j.ijsolstr.2007.06.017	en
heal.identifier.secondary	http://dx.doi.org/10.1016/j.ijsolstr.2007.06.017	en
heal.language	English	en
heal.publicationDate	2007	en
heal.abstract	It is well known that substrate stretching reorganizes the actin cytoskeleton of an adherent cell. Experiments have proved that the stress fibers are reoriented into one or two distinct directions. It is further pointed out that reorientation of the stress fibers phenomena are observed with quite high strains, where linear elasticity theory is not valid. Therefore, the existing linear theories for mechanics interpretation of those phenomena are not satisfactory. The experimental evidence of the existence of two distinct directions of the reorientation indicates a co-existence of phases non-linear elastic phenomenon. Further that observation is quite strong evidence that the strain energy density function should be non-convex. The reorganization of the stress fibers under uniaxial substrate stretching is studied as a non-linear elastic stability problem. Adapting the global (Maxwell's) criterion for stability, various phenomena, concerning the reorientation of the stress fibers, are interpreted into the context of finite elasticity. The experiments demonstrate co-existence of phases phenomena that are justified in the present study. The influence of various factors like contractility and extracellular stretching is demonstrated. Furthermore, the non-convexity factor is attributed to the influence of the small GTPase Rho regulating the formation of the actin stress fibers. The predominant final stress fibers placement that is transverse to the extracellular stress direction and appears in long time after the co-existence of phases placement is also justified. (c) 2007 Elsevier Ltd. All rights reserved.	en
heal.publisher	PERGAMON-ELSEVIER SCIENCE LTD	en
heal.journalName	International Journal of Solids and Structures	en
dc.identifier.doi	10.1016/j.ijsolstr.2007.06.017	en
dc.identifier.isi	ISI:000251775400013	en
dc.identifier.volume	44	en
dc.identifier.issue	25-26	en
dc.identifier.spage	8285	en
dc.identifier.epage	8296	en