Blood pressure estimation in the human fetal descending aorta

Struijk, PC; Mathews, VJ; Loupas, T; Stewart, PA; Clark, EB; Steegers, EAP; Wladimiroff, JW

dc.contributor.author	Struijk, PC	en
dc.contributor.author	Mathews, VJ	en
dc.contributor.author	Loupas, T	en
dc.contributor.author	Stewart, PA	en
dc.contributor.author	Clark, EB	en
dc.contributor.author	Steegers, EAP	en
dc.contributor.author	Wladimiroff, JW	en
dc.date.accessioned	2014-03-01T01:28:01Z
dc.date.available	2014-03-01T01:28:01Z
dc.date.issued	2008	en
dc.identifier.issn	0960-7692	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18668
dc.subject	Arterial blood pressure	en
dc.subject	Compliance	en
dc.subject	Fetus	en
dc.subject	Peripheral resistance	en
dc.subject.classification	Acoustics	en
dc.subject.classification	Obstetrics & Gynecology	en
dc.subject.classification	Radiology, Nuclear Medicine & Medical Imaging	en
dc.subject.other	aorta flow	en
dc.subject.other	aorta pressure	en
dc.subject.other	article	en
dc.subject.other	blood pressure measurement	en
dc.subject.other	color ultrasound flowmetry	en
dc.subject.other	comparative study	en
dc.subject.other	controlled study	en
dc.subject.other	descending aorta	en
dc.subject.other	diastolic blood pressure	en
dc.subject.other	female	en
dc.subject.other	fetus	en
dc.subject.other	gestational age	en
dc.subject.other	heart left ventricle contraction	en
dc.subject.other	human	en
dc.subject.other	human experiment	en
dc.subject.other	normal human	en
dc.subject.other	pregnancy	en
dc.subject.other	priority journal	en
dc.subject.other	pulse wave	en
dc.subject.other	systolic blood pressure	en
dc.subject.other	umbilical artery	en
dc.subject.other	vascular resistance	en
dc.subject.other	Aorta, Thoracic	en
dc.subject.other	Blood Pressure	en
dc.subject.other	Feasibility Studies	en
dc.subject.other	Fetus	en
dc.subject.other	Gestational Age	en
dc.subject.other	Heart Rate, Fetal	en
dc.subject.other	Humans	en
dc.subject.other	Pulsatile Flow	en
dc.subject.other	Regression Analysis	en
dc.subject.other	Ultrasonography, Doppler, Color	en
dc.subject.other	Ultrasonography, Prenatal	en
dc.subject.other	Vascular Resistance	en
dc.title	Blood pressure estimation in the human fetal descending aorta	en
heal.type	journalArticle	en
heal.identifier.primary	10.1002/uog.6137	en
heal.identifier.secondary	http://dx.doi.org/10.1002/uog.6137	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	Objectives: The objectives of this study were to estimate fetal blood pressure non-invasively from two-dimensional color Doppler-derived aortic blood flow and diameter waveforms, and to compare the results with invasively derived human fetal blood pressures available from the literature. Methods: Aortic pressures were calculated from digitally recorded color Doppler cineloops of the fetal descending aorta by applying the Womersley model in combination with the two-element Windkessel model, assuming constant pulse wave velocity during the second half of pregnancy. The results were compared with invasively derived human fetal blood pressures obtained from the literature. Results: In 21 normal pregnancies the estimated mean aortic pressure regression line increased linearly from 28 mmHg at 20 weeks of gestation to 45 mmHg at 40 weeks of gestation. The pulse pressure based on the regression line increased linearly from 21 mmHg at 20 weeks of gestation to 29 mmHg at 40 weeks of gestation. The aortic compliance exhibited a log linear relationship with the gestational age and a statistically significant eightfold increase was observed between 20 and 40 weeks. The aortic downstream peripheral resistance exhibited an exponentially decaying relationship across the same gestational age range. Non-invasively derived aortic systolic and diastolic aortic pressures were comparable with previously reported invasively derived systolic and diastolic umbilical arterial pressures; however, the mean pressures differed significantly from those reported in the umbilical artery in a separate study. The aortic systolic pressures calculated in this study were significantly higher than invasively derived left ventricular systolic pressures that have been previously reported in the literature. Conclusions: This study demonstrates the feasibility of estimating arterial blood pressure in the human fetus. The method described is of potential use in assessing fetal blood pressure non-invasively, particularly for studying relative changes with time. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.	en
heal.publisher	JOHN WILEY & SONS LTD	en
heal.journalName	Ultrasound in Obstetrics and Gynecology	en
dc.identifier.doi	10.1002/uog.6137	en
dc.identifier.isi	ISI:000261044100014	en
dc.identifier.volume	32	en
dc.identifier.issue	5	en
dc.identifier.spage	673	en
dc.identifier.epage	681	en