Development and laboratory testing of a noninvasive intracranial focused hyperthermia system

Karanasiou, IS; Karathanasis, KT; Garetsos, A; Uzunoglu, NK

dc.contributor.author	Karanasiou, IS	en
dc.contributor.author	Karathanasis, KT	en
dc.contributor.author	Garetsos, A	en
dc.contributor.author	Uzunoglu, NK	en
dc.date.accessioned	2014-03-01T01:28:08Z
dc.date.available	2014-03-01T01:28:08Z
dc.date.issued	2008	en
dc.identifier.issn	0018-9480	en
dc.identifier.uri	https://dspace.lib.ntua.gr/xmlui/handle/123456789/18728
dc.subject	Ellipsoidal conductive reflector	en
dc.subject	Focusing properties	en
dc.subject	Hyperthermia	en
dc.subject	Microwave radiometry	en
dc.subject	Noninvasive contactless methodology	en
dc.subject.classification	Engineering, Electrical & Electronic	en
dc.subject.other	Computer networks	en
dc.subject.other	Electric network analysis	en
dc.subject.other	Ellipsoidal conductive reflector	en
dc.subject.other	Focusing properties	en
dc.subject.other	Hyperthermia	en
dc.subject.other	Microwave radiometry	en
dc.subject.other	Noninvasive contactless methodology	en
dc.subject.other	Dielectric materials	en
dc.title	Development and laboratory testing of a noninvasive intracranial focused hyperthermia system	en
heal.type	journalArticle	en
heal.identifier.primary	10.1109/TMTT.2008.2002227	en
heal.identifier.secondary	http://dx.doi.org/10.1109/TMTT.2008.2002227	en
heal.identifier.secondary	4599250	en
heal.language	English	en
heal.publicationDate	2008	en
heal.abstract	During the past two decades, a great deal of research has been carried out with the aim of developing effective techniques for hyperthermia treatment, primarily using RF, microwave, and ultrasound energy. A system for deep brain hyperthermia treatment, designed to also provide passive measurements of temperature and/or conductivity variations inside the human body, is presented in this paper. The proposed system comprises both therapeutic and diagnostic modules, operating in a totally contactless way, based on the use of an ellipsoidal beamformer to achieve focusing on the areas under treatment and monitoring. In previous publications, the performance of the system's diagnostic module in phantom, animal, and human studies has been reported. In the current research, new theoretical and experimental results using the therapeutic hyperthermia module of the system are presented. The main scope of the theoretical analysis is the improvement of the system's focusing attributes. Moreover, phantom experimental results verify the proof of concept. Both computation and phantom measurement results show that deep focused brain hyperthermia may be achievable with adequate spatial resolution and sensitivity using the proposed methodology, subject to the appropriate combination of operation frequency and low-loss dielectric material used as filling in the ellipsoidal. © 2008 IEEE.	en
heal.publisher	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC	en
heal.journalName	IEEE Transactions on Microwave Theory and Techniques	en
dc.identifier.doi	10.1109/TMTT.2008.2002227	en
dc.identifier.isi	ISI:000259192500019	en
dc.identifier.volume	56	en
dc.identifier.issue	9	en
dc.identifier.spage	2160	en
dc.identifier.epage	2171	en